D2 dopamine receptor gene and obesity

E. P. Noble, R. E. Noble, T. Ritchie, K. Syndulko, M. C. Bohlman, L. A. Noble, Y. Zhang, R. S. Sparkes, David Grandy

    Research output: Contribution to journalArticle

    157 Citations (Scopus)

    Abstract

    The prevalence of Taql A D2 dopamine receptor (DRD2) alleles was determined in 73 obese women and men. In this sample with a mean body mass index of 35.1, the A1 (minor) allele of the DRD2 gene was present in 45.2% of these nonalcohol, nondrug abusing subjects. The DRD2 A1 allele was not associated with a number of cardiovascular risk factors examined, including blood lipids (cholesterol, high-density lipoprotein [HDL]- and low-density lipoprotein [LDL]-cholesterol, and triglycerides). However, phenotypic factors characterized by the presence of parental history and postpuberty onset of obesity as well as carbohydrate preference were associated with obese subjects carrying the A1 allele. The cumulative number of these three factors was positively and significantly (p <.0002) related to A1 allelic prevalence. The data showing an association of the minor allele of the DRD2 gene with phenotypic characteristics suggest that this gene, located on q22- q23 region of chromosome 11, confers susceptibility to a subtype of this disorder.

    Original languageEnglish (US)
    Pages (from-to)205-217
    Number of pages13
    JournalInternational Journal of Eating Disorders
    Volume15
    Issue number3
    StatePublished - 1994

    Fingerprint

    Dopamine D2 Receptors
    obesity
    Obesity
    Alleles
    alleles
    Genes
    genes
    Chromosomes, Human, Pair 11
    low density lipoprotein cholesterol
    high density lipoprotein cholesterol
    blood lipids
    LDL Cholesterol
    HDL Cholesterol
    body mass index
    Body Mass Index
    risk factors
    triacylglycerols
    Carbohydrates
    dopamine receptors
    carbohydrates

    ASJC Scopus subject areas

    • Food Science
    • Medicine (miscellaneous)
    • Psychiatry and Mental health
    • Psychology(all)
    • Clinical Psychology

    Cite this

    Noble, E. P., Noble, R. E., Ritchie, T., Syndulko, K., Bohlman, M. C., Noble, L. A., ... Grandy, D. (1994). D2 dopamine receptor gene and obesity. International Journal of Eating Disorders, 15(3), 205-217.

    D2 dopamine receptor gene and obesity. / Noble, E. P.; Noble, R. E.; Ritchie, T.; Syndulko, K.; Bohlman, M. C.; Noble, L. A.; Zhang, Y.; Sparkes, R. S.; Grandy, David.

    In: International Journal of Eating Disorders, Vol. 15, No. 3, 1994, p. 205-217.

    Research output: Contribution to journalArticle

    Noble, EP, Noble, RE, Ritchie, T, Syndulko, K, Bohlman, MC, Noble, LA, Zhang, Y, Sparkes, RS & Grandy, D 1994, 'D2 dopamine receptor gene and obesity', International Journal of Eating Disorders, vol. 15, no. 3, pp. 205-217.
    Noble EP, Noble RE, Ritchie T, Syndulko K, Bohlman MC, Noble LA et al. D2 dopamine receptor gene and obesity. International Journal of Eating Disorders. 1994;15(3):205-217.
    Noble, E. P. ; Noble, R. E. ; Ritchie, T. ; Syndulko, K. ; Bohlman, M. C. ; Noble, L. A. ; Zhang, Y. ; Sparkes, R. S. ; Grandy, David. / D2 dopamine receptor gene and obesity. In: International Journal of Eating Disorders. 1994 ; Vol. 15, No. 3. pp. 205-217.
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    abstract = "The prevalence of Taql A D2 dopamine receptor (DRD2) alleles was determined in 73 obese women and men. In this sample with a mean body mass index of 35.1, the A1 (minor) allele of the DRD2 gene was present in 45.2{\%} of these nonalcohol, nondrug abusing subjects. The DRD2 A1 allele was not associated with a number of cardiovascular risk factors examined, including blood lipids (cholesterol, high-density lipoprotein [HDL]- and low-density lipoprotein [LDL]-cholesterol, and triglycerides). However, phenotypic factors characterized by the presence of parental history and postpuberty onset of obesity as well as carbohydrate preference were associated with obese subjects carrying the A1 allele. The cumulative number of these three factors was positively and significantly (p <.0002) related to A1 allelic prevalence. The data showing an association of the minor allele of the DRD2 gene with phenotypic characteristics suggest that this gene, located on q22- q23 region of chromosome 11, confers susceptibility to a subtype of this disorder.",
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    AU - Noble, E. P.

    AU - Noble, R. E.

    AU - Ritchie, T.

    AU - Syndulko, K.

    AU - Bohlman, M. C.

    AU - Noble, L. A.

    AU - Zhang, Y.

    AU - Sparkes, R. S.

    AU - Grandy, David

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    AB - The prevalence of Taql A D2 dopamine receptor (DRD2) alleles was determined in 73 obese women and men. In this sample with a mean body mass index of 35.1, the A1 (minor) allele of the DRD2 gene was present in 45.2% of these nonalcohol, nondrug abusing subjects. The DRD2 A1 allele was not associated with a number of cardiovascular risk factors examined, including blood lipids (cholesterol, high-density lipoprotein [HDL]- and low-density lipoprotein [LDL]-cholesterol, and triglycerides). However, phenotypic factors characterized by the presence of parental history and postpuberty onset of obesity as well as carbohydrate preference were associated with obese subjects carrying the A1 allele. The cumulative number of these three factors was positively and significantly (p <.0002) related to A1 allelic prevalence. The data showing an association of the minor allele of the DRD2 gene with phenotypic characteristics suggest that this gene, located on q22- q23 region of chromosome 11, confers susceptibility to a subtype of this disorder.

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