D1 and D2 dopamine receptor distribution in the neuroleptic nonresponsive and neuroleptic responsive lines of mice, a quantitative receptor autoradiographic study

Y. Qian, B. Hitzemann, Robert Hitzemann

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The present study uses quantitative receptor autoradiography to examine D1 and D2 receptor binding in the neuroleptic responsive and neuroleptic nonresponsive (NNR) lines of mice. The neuroleptic responsive and NNR mice have differed for at least eight generations by an order of magnitude in their sensitivity (ED(50s)) to catalepsy induced by neuroleptics with a high D2/D1 receptor activity profile. Across the entire rostral-caudal dimensions of the lateral caudate-putamen (CPu), of the dorsomedial CPu, the nucleus accumbens and substantia nigra zona reticulata, we found no difference in the density of [3H]SCH 23390 binding sites. [3H]Spiroperidol binding sites were not different in the dorsomedial CPu or nucleus accumbens but were significantly decreased (20-30%) in the NNR line in the caudal aspect of the lateral CPu. The NNR line also showed a significant elevation of D2 autoreceptors across all the midbrain dopamine cell groups (A8, A9, and A10); the increases ranged from 20 to 50%. Overall, the data show that selection of mice for response and nonresponse to neuroleptic-induced catalepsy is associated with significant changes in D2 but not D1 receptor density.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume261
Issue number1
StatePublished - 1992
Externally publishedYes

Fingerprint

Dopamine D1 Receptors
Dopamine D2 Receptors
Antipsychotic Agents
Putamen
Catalepsy
Nucleus Accumbens
Binding Sites
Spiperone
Autoreceptors
Caudate Nucleus
antineoplaston A10
Herpes Zoster
Mesencephalon
Autoradiography
Dopamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{cdbb445a4ee64e8692340393d7431bb3,
title = "D1 and D2 dopamine receptor distribution in the neuroleptic nonresponsive and neuroleptic responsive lines of mice, a quantitative receptor autoradiographic study",
abstract = "The present study uses quantitative receptor autoradiography to examine D1 and D2 receptor binding in the neuroleptic responsive and neuroleptic nonresponsive (NNR) lines of mice. The neuroleptic responsive and NNR mice have differed for at least eight generations by an order of magnitude in their sensitivity (ED(50s)) to catalepsy induced by neuroleptics with a high D2/D1 receptor activity profile. Across the entire rostral-caudal dimensions of the lateral caudate-putamen (CPu), of the dorsomedial CPu, the nucleus accumbens and substantia nigra zona reticulata, we found no difference in the density of [3H]SCH 23390 binding sites. [3H]Spiroperidol binding sites were not different in the dorsomedial CPu or nucleus accumbens but were significantly decreased (20-30{\%}) in the NNR line in the caudal aspect of the lateral CPu. The NNR line also showed a significant elevation of D2 autoreceptors across all the midbrain dopamine cell groups (A8, A9, and A10); the increases ranged from 20 to 50{\%}. Overall, the data show that selection of mice for response and nonresponse to neuroleptic-induced catalepsy is associated with significant changes in D2 but not D1 receptor density.",
author = "Y. Qian and B. Hitzemann and Robert Hitzemann",
year = "1992",
language = "English (US)",
volume = "261",
pages = "341--348",
journal = "Journal of Pharmacology and Experimental Therapeutics",
issn = "0022-3565",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "1",

}

TY - JOUR

T1 - D1 and D2 dopamine receptor distribution in the neuroleptic nonresponsive and neuroleptic responsive lines of mice, a quantitative receptor autoradiographic study

AU - Qian, Y.

AU - Hitzemann, B.

AU - Hitzemann, Robert

PY - 1992

Y1 - 1992

N2 - The present study uses quantitative receptor autoradiography to examine D1 and D2 receptor binding in the neuroleptic responsive and neuroleptic nonresponsive (NNR) lines of mice. The neuroleptic responsive and NNR mice have differed for at least eight generations by an order of magnitude in their sensitivity (ED(50s)) to catalepsy induced by neuroleptics with a high D2/D1 receptor activity profile. Across the entire rostral-caudal dimensions of the lateral caudate-putamen (CPu), of the dorsomedial CPu, the nucleus accumbens and substantia nigra zona reticulata, we found no difference in the density of [3H]SCH 23390 binding sites. [3H]Spiroperidol binding sites were not different in the dorsomedial CPu or nucleus accumbens but were significantly decreased (20-30%) in the NNR line in the caudal aspect of the lateral CPu. The NNR line also showed a significant elevation of D2 autoreceptors across all the midbrain dopamine cell groups (A8, A9, and A10); the increases ranged from 20 to 50%. Overall, the data show that selection of mice for response and nonresponse to neuroleptic-induced catalepsy is associated with significant changes in D2 but not D1 receptor density.

AB - The present study uses quantitative receptor autoradiography to examine D1 and D2 receptor binding in the neuroleptic responsive and neuroleptic nonresponsive (NNR) lines of mice. The neuroleptic responsive and NNR mice have differed for at least eight generations by an order of magnitude in their sensitivity (ED(50s)) to catalepsy induced by neuroleptics with a high D2/D1 receptor activity profile. Across the entire rostral-caudal dimensions of the lateral caudate-putamen (CPu), of the dorsomedial CPu, the nucleus accumbens and substantia nigra zona reticulata, we found no difference in the density of [3H]SCH 23390 binding sites. [3H]Spiroperidol binding sites were not different in the dorsomedial CPu or nucleus accumbens but were significantly decreased (20-30%) in the NNR line in the caudal aspect of the lateral CPu. The NNR line also showed a significant elevation of D2 autoreceptors across all the midbrain dopamine cell groups (A8, A9, and A10); the increases ranged from 20 to 50%. Overall, the data show that selection of mice for response and nonresponse to neuroleptic-induced catalepsy is associated with significant changes in D2 but not D1 receptor density.

UR - http://www.scopus.com/inward/record.url?scp=0026612747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026612747&partnerID=8YFLogxK

M3 - Article

VL - 261

SP - 341

EP - 348

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 1

ER -