Abstract
Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg group. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 647-652 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
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Keywords
- d-Amphetamine
- Facilitation of learning
- Inbred mice
- Learning
- Long-term store of memory
- Memory
- Memory disruption
- Proactive facilitation
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
d-Amphetamine : Disruptive effects on the long-term store of memory and proactive facilitatory effects on learning in inbred mice. / Crabbe, John Jr; Alpern, Herbert P.
In: Pharmacology, Biochemistry and Behavior, Vol. 3, No. 4, 1975, p. 647-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - d-Amphetamine
T2 - Disruptive effects on the long-term store of memory and proactive facilitatory effects on learning in inbred mice
AU - Crabbe, John Jr
AU - Alpern, Herbert P.
PY - 1975
Y1 - 1975
N2 - Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg group. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.
AB - Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg group. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.
KW - d-Amphetamine
KW - Facilitation of learning
KW - Inbred mice
KW - Learning
KW - Long-term store of memory
KW - Memory
KW - Memory disruption
KW - Proactive facilitation
UR - http://www.scopus.com/inward/record.url?scp=0016834645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016834645&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(75)90186-0
DO - 10.1016/0091-3057(75)90186-0
M3 - Article
C2 - 1187728
AN - SCOPUS:0016834645
VL - 3
SP - 647
EP - 652
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -