d-Amphetamine: Disruptive effects on the long-term store of memory and proactive facilitatory effects on learning in inbred mice

John C. Crabbe, Herbert P. Alpern

Research output: Contribution to journalArticle

3 Scopus citations


Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg group. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.

Original languageEnglish (US)
Pages (from-to)647-652
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Issue number4
StatePublished - Jan 1 1975



  • Facilitation of learning
  • Inbred mice
  • Learning
  • Long-term store of memory
  • Memory
  • Memory disruption
  • Proactive facilitation
  • d-Amphetamine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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