Abstract
Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg group. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.
Original language | English (US) |
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Pages (from-to) | 647-652 |
Number of pages | 6 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 1975 |
Keywords
- Facilitation of learning
- Inbred mice
- Learning
- Long-term store of memory
- Memory
- Memory disruption
- Proactive facilitation
- d-Amphetamine
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience