Cytotoxicity of dimethyl sulfoxide and antineoplastic combinations against human tumors

Rodney Pommier, Eugene A. Woltering, George Milo, William S. Fletcher

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Five human tumor reference cell lines were tested in vitro against 0 percent, 5 percent, and 10 percent DMSO; four antineoplastic agents; and combinations of 5 percent or 10 percent DMSO plus each antineoplastic agent. Synergistic cytotoxicity between DMSO and antineoplastic agents against each cell line were demonstrated. We have concluded that delivery of standard doses of antineoplastic agents in 5 percent or 10 percent DMSO may be useful in the treatment of some tumors because of the marked increase in tumoricidal effect seen with some DMSO and drug combinations. Alternatively, lower doses of antineoplastic agents might be delivered in DMSO, producing the same cytotoxic effect as a full dose of drug without DMSO but with less systemic toxicity.

Original languageEnglish (US)
Pages (from-to)672-676
Number of pages5
JournalThe American Journal of Surgery
Volume155
Issue number5
DOIs
StatePublished - 1988
Externally publishedYes

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Dimethyl Sulfoxide
Antineoplastic Agents
Neoplasms
Drug Combinations
Tumor Cell Line
Cell Line
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Surgery

Cite this

Cytotoxicity of dimethyl sulfoxide and antineoplastic combinations against human tumors. / Pommier, Rodney; Woltering, Eugene A.; Milo, George; Fletcher, William S.

In: The American Journal of Surgery, Vol. 155, No. 5, 1988, p. 672-676.

Research output: Contribution to journalArticle

Pommier, Rodney ; Woltering, Eugene A. ; Milo, George ; Fletcher, William S. / Cytotoxicity of dimethyl sulfoxide and antineoplastic combinations against human tumors. In: The American Journal of Surgery. 1988 ; Vol. 155, No. 5. pp. 672-676.
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