Cytotoxicity of dimethyl sulfoxide and antineoplastic combinations against human tumors

Rodney F. Pommier, Eugene A. Woltering, George Milo, William S. Fletcher

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Five human tumor reference cell lines were tested in vitro against 0 percent, 5 percent, and 10 percent DMSO; four antineoplastic agents; and combinations of 5 percent or 10 percent DMSO plus each antineoplastic agent. Synergistic cytotoxicity between DMSO and antineoplastic agents against each cell line were demonstrated. We have concluded that delivery of standard doses of antineoplastic agents in 5 percent or 10 percent DMSO may be useful in the treatment of some tumors because of the marked increase in tumoricidal effect seen with some DMSO and drug combinations. Alternatively, lower doses of antineoplastic agents might be delivered in DMSO, producing the same cytotoxic effect as a full dose of drug without DMSO but with less systemic toxicity.

Original languageEnglish (US)
Pages (from-to)672-676
Number of pages5
JournalThe American Journal of Surgery
Volume155
Issue number5
DOIs
StatePublished - May 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Cytotoxicity of dimethyl sulfoxide and antineoplastic combinations against human tumors'. Together they form a unique fingerprint.

Cite this