Cytoplasmic fatty acid-binding proteins

Emerging roles in metabolism and atherosclerosis

Jeffrey B. Boord, Sergio Fazio, MacRae F. Linton

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Cytoplasmic fatty acid-binding proteins (FABPs) are a family of proteins, expressed in a tissue-specific manner, that bind fatty acid ligands and are involved in shuttling fatty acids to cellular compartments, modulating intracellular lipid metabolism, and regulating gene expression. Several members of the FABP family have been shown to have important roles in regulating metabolism and have links to the development of insulin resistance and the metabolic syndrome. Recent studies demonstrate a role for intestinal FABP in the control of dietary fatty acid absorption and chylomicron secretion. Heart FABP is essential for normal myocardial fatty acid oxidation and modulates fatty acid uptake in skeletal muscle. Liver FABP is directly involved in fatty acid ligand signaling to the nucleus and interacts with peroxisome proliferator-activated receptors in hepatocytes. The adipocyte FABP (aP2) has been shown to affect insulin sensitivity, lipid metabolism and lipolysis, and has recently been shown to play an important role in atherosclerosis. Interestingly, expression of aP2 by the macrophage promotes atherogenesis, thus providing a link between insulin resistance, intracellular fatty acid disposition, and foam cell formation. The FABPs are promising targets for the treatment of dyslipidemia, insulin resistance, and atherosclerosis in humans.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalCurrent Opinion in Lipidology
Volume13
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

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Fatty Acid-Binding Proteins
Metabolism
Atherosclerosis
Fatty Acids
Insulin Resistance
Insulin
Lipid Metabolism
Ligands
Chylomicrons
Foam Cells
Peroxisome Proliferator-Activated Receptors
Macrophages
Lipolysis
Dyslipidemias
Adipocytes
Gene expression
Muscle
Foams
Hepatocytes
Skeletal Muscle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cytoplasmic fatty acid-binding proteins : Emerging roles in metabolism and atherosclerosis. / Boord, Jeffrey B.; Fazio, Sergio; Linton, MacRae F.

In: Current Opinion in Lipidology, Vol. 13, No. 2, 2002, p. 141-147.

Research output: Contribution to journalArticle

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