Cytoplasmic and cytoskeletal regulation of glutamate receptor channels

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Abstract

The regulation of glutamate receptor channels by intracellular messengers is an important component in the plasticity of central excitatory synapses. This review summarizes recent evidence demonstrating that phosphorylation, intracellular calcium and interactions with cytoskeletal proteins can dramatically influence the properties of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor channels. Kinases and intracellular calcium exert their action either directly on glutamate receptor channel subunits or indirectly via regulatory proteins or second messenger cascades. Recent evidence also suggests that interactions with cytoskeletal proteins play a dynamic role in regulating the gating of glutamate receptor channels. These studies provide tantalizing evidence for a complex set of regulatory interactions in the postsynaptic density.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalSeminars in Neuroscience
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1994

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Keywords

  • Calcium
  • Cytoskeletonion channels
  • NMDA receptors
  • Phoshorylation

ASJC Scopus subject areas

  • Neuroscience(all)

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