Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility

Sunwen Chou, Terry L. Bowlin

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Among the 7 most common UL97 mutations encountered in ganciclovir-resistant clinical cytomegalovirus isolates, the associated cyclopropavir cross-resistance varies from insignificant (L595S) to substantial (M460I and H520Q) as determined by recombinant phenotyping. Mutations M460I and H520Q were preferentially selected in vitro under cyclopropavir and conferred 12- to 20-fold increases in 50% effective concentration (EC50) values, while M460V, C592G, A594V, and C603W conferred 3- to 5-fold increases. Uncommon mutations M460T and C603R increased cyclopropavir EC50s by 8- to 10-fold.

Original languageEnglish (US)
Pages (from-to)382-384
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number1
DOIs
StatePublished - Jan 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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