TY - JOUR
T1 - Cytomegalovirus microRNAs
AU - Hook, Lauren
AU - Hancock, Meaghan
AU - Landais, Igor
AU - Grabski, Robert
AU - Britt, William
AU - Nelson, Jay A.
N1 - Funding Information:
This review was supported by NIH / NIAID grant AI021640 to J.A.N. We would like to thank A. Townsend for help with the illustrations. We acknowledge the important contribution of those researchers whose work was not fully cited due to space limitations.
PY - 2014/8
Y1 - 2014/8
N2 - The discovery that animals, plants and DNA viruses encode microRNAs (miRNAs) has transformed our understanding of the regulation of gene expression. miRNAs are ubiquitous small non-coding RNAs that regulate gene expression post-transcriptionally, generally by binding to sites within the 3′ untranslated regions (UTR) of messenger RNA (mRNA) transcripts. To date, over 250 viral miRNAs have been identified primarily in members of the herpesvirus family. These viral miRNAs target both viral and cellular genes in order to regulate viral replication, the establishment and maintenance of viral latency, cell survival, and innate and adaptive immunity. This review will focus on our current knowledge of the targets and functions of human cytomegalovirus (HCMV) miRNAs and their functional equivalents in other herpesviruses.
AB - The discovery that animals, plants and DNA viruses encode microRNAs (miRNAs) has transformed our understanding of the regulation of gene expression. miRNAs are ubiquitous small non-coding RNAs that regulate gene expression post-transcriptionally, generally by binding to sites within the 3′ untranslated regions (UTR) of messenger RNA (mRNA) transcripts. To date, over 250 viral miRNAs have been identified primarily in members of the herpesvirus family. These viral miRNAs target both viral and cellular genes in order to regulate viral replication, the establishment and maintenance of viral latency, cell survival, and innate and adaptive immunity. This review will focus on our current knowledge of the targets and functions of human cytomegalovirus (HCMV) miRNAs and their functional equivalents in other herpesviruses.
UR - http://www.scopus.com/inward/record.url?scp=84899422875&partnerID=8YFLogxK
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U2 - 10.1016/j.coviro.2014.03.015
DO - 10.1016/j.coviro.2014.03.015
M3 - Review article
C2 - 24769092
AN - SCOPUS:84899422875
SN - 1879-6257
VL - 7
SP - 40
EP - 46
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 1
ER -