Cytomegalovirus immune evasion

C. Powers, Victor De Filippis, D. Malouli, Klaus Frueh

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Human cytomegalovirus (HCMV) has become a paradigm for viral immune evasion due to its unique multitude of immune-modulatory strategies. HCMV modulates the innate as well as adaptive immune response at every step of its life cycle. It dampens the induction of antiviral interferon-induced genes by several mechanisms. Further striking is the multitude of genes and strategies devoted to modulating and escaping the cellular immune response. Several genes are independently capable of inhibiting antigen presentation to cytolytic T cells by downregulating MHC class I. Recent data revealed an astounding variety of methods in triggering or inhibiting activatory and inhibitory receptors found on NK cells, NKT cells, T cells as well as auxiliary cells of the immune system. The multitude and complexity of these mechanisms is fascinating and continues to reveal novel insights into the host-pathogen interaction and novel cell biological and immunological concepts.

Original languageEnglish (US)
Pages (from-to)333-359
Number of pages27
JournalCurrent Topics in Microbiology and Immunology
Volume325
DOIs
StatePublished - 2008

Fingerprint

Immune Evasion
Cytomegalovirus
Genes
T-Lymphocytes
Host-Pathogen Interactions
Natural Killer T-Cells
Antigen Presentation
Adaptive Immunity
Life Cycle Stages
Innate Immunity
Cellular Immunity
Natural Killer Cells
Interferons
Antiviral Agents
Immune System
Down-Regulation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology
  • Microbiology
  • Immunology and Microbiology(all)

Cite this

Cytomegalovirus immune evasion. / Powers, C.; De Filippis, Victor; Malouli, D.; Frueh, Klaus.

In: Current Topics in Microbiology and Immunology, Vol. 325, 2008, p. 333-359.

Research output: Contribution to journalArticle

Powers, C. ; De Filippis, Victor ; Malouli, D. ; Frueh, Klaus. / Cytomegalovirus immune evasion. In: Current Topics in Microbiology and Immunology. 2008 ; Vol. 325. pp. 333-359.
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