TY - JOUR
T1 - Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients
AU - Rasmussen, Lucy
AU - Hong, Christina
AU - Zipeto, Donate
AU - Morris, Shannon
AU - Sherman, Daniel
AU - Chou, Sunwen
AU - Miner, Richard
AU - Drew, W. Lawrence
AU - Wolitz, Richard
AU - Dowling, Anna
AU - Warlord, Ann
AU - Merigan, Thomas C.
PY - 1997
Y1 - 1997
N2 - Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%, 43%, and 0% and 39%, 30%, 17%, and 13%. However, in leukocytes of HIV-infected patients with <100/μL CD4 cells, gB1 was found significantly less often than in allograft recipients (11% vs. 36%) but gB2 was more frequent (56% vs. 21%; P < .05). The decreased incidence of gB1 and increased incidence of gB2 compared with allograft recipients was also seen in urine of HIV-infected patients and reflected the distribution seen in leukocytes. gB4 was found significantly more often (P < .05) in semen than in leukocytes of HIV-infected patients with < 100/μL CD4 cells. gB1-4 genotypes were similar in patients with <100/μL CD4 cells with or without retinitis.
AB - Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%, 43%, and 0% and 39%, 30%, 17%, and 13%. However, in leukocytes of HIV-infected patients with <100/μL CD4 cells, gB1 was found significantly less often than in allograft recipients (11% vs. 36%) but gB2 was more frequent (56% vs. 21%; P < .05). The decreased incidence of gB1 and increased incidence of gB2 compared with allograft recipients was also seen in urine of HIV-infected patients and reflected the distribution seen in leukocytes. gB4 was found significantly more often (P < .05) in semen than in leukocytes of HIV-infected patients with < 100/μL CD4 cells. gB1-4 genotypes were similar in patients with <100/μL CD4 cells with or without retinitis.
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U2 - 10.1093/infdis/175.1.179
DO - 10.1093/infdis/175.1.179
M3 - Article
C2 - 8985216
AN - SCOPUS:16944366760
SN - 0022-1899
VL - 175
SP - 179
EP - 184
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -