Cytomegalovirus gB genotype distribution differs in human immunodeficiency virus-infected patients and immunocompromised allograft recipients

Lucy Rasmussen, Christina Hong, Donate Zipeto, Shannon Morris, Daniel Sherman, Sunwen Chou, Richard Miner, W. Lawrence Drew, Richard Wolitz, Anna Dowling, Ann Warlord, Thomas C. Merigan

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Cytomegalovirus isolates can be grouped into 4 gB and 2 gH genotypes. gB genotypes were studied in patients infected with human immunodeficiency virus (HIV) and in allograft transplantation recipients. In allograft recipients, the distribution of gB1, -2, -3, and -4 in leukocytes and urine, respectively, was 36%, 21%, 43%, and 0% and 39%, 30%, 17%, and 13%. However, in leukocytes of HIV-infected patients with <100/μL CD4 cells, gB1 was found significantly less often than in allograft recipients (11% vs. 36%) but gB2 was more frequent (56% vs. 21%; P < .05). The decreased incidence of gB1 and increased incidence of gB2 compared with allograft recipients was also seen in urine of HIV-infected patients and reflected the distribution seen in leukocytes. gB4 was found significantly more often (P < .05) in semen than in leukocytes of HIV-infected patients with < 100/μL CD4 cells. gB1-4 genotypes were similar in patients with <100/μL CD4 cells with or without retinitis.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalJournal of Infectious Diseases
Volume175
Issue number1
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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