Cytogenetic evidence for involvement of B lymphocytes in acquired idiopathic sideroblastic anemias

H. J. Lawrence, V. C. Broudy, R. E. Magenis, S. Olson, D. Tomar, S. Barton, J. H. Fitchen, G. C. Bagby

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

We studied the cellular distribution of an unusual chromosomal abnormality, an interstitial deletion of the long arm of chromosome 13, in the peripheral blood lymphocytes of two patients with acquired idiopathic sideroblastic anemia (AISA). We found no metaphases containing the 13q-abnormality in preparations of phytohemagglutinin (PHA)-stimulated lymphocytes from either patient. In both cases, however, some metaphases from Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines contained the clonal karyotypic abnormality. These observations indicate that B lymphocytes but not T cells are expressed as members of the clonal cohort of cells. Our results strongly suggest that the initial pathogenetic events that led to expansion of the 13q- clone occurred in a progenitor cell capable of giving rise to both hematopoietic and B lymphoid cells.

Original languageEnglish (US)
Pages (from-to)1003-1005
Number of pages3
JournalBlood
Volume70
Issue number4
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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