Cytogenetic analysis of a primary bone angiosarcoma

Jennifer B. Dunlap, R. Ellen Magenis, Craig Davis, Eleanor Himoe, Atiya Mansoor

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Primary bone angiosarcomas are rare and aggressive vascular malignancies with a high mortality rate. To our knowledge, there are no reported cytogenetic abnormalities in primary bone angiosarcomas, although several have been reported in soft tissue angiosarcomas. We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma. The biologic significance of this translocation is not clear; however, the 1p21 locus is in the region of colony stimulating factor (CSF-1), which may play a role in tumorigenesis, as has been described in pigmented villonodular synovitis and tenosynovial giant cell tumor.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume194
Issue number1
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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