Cytogenetic analysis of a primary bone angiosarcoma

Jennifer Dunlap, R. Ellen Magenis, Craig Davis, Eleanor Himoe, Atiya Mansoor

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Primary bone angiosarcomas are rare and aggressive vascular malignancies with a high mortality rate. To our knowledge, there are no reported cytogenetic abnormalities in primary bone angiosarcomas, although several have been reported in soft tissue angiosarcomas. We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma. The biologic significance of this translocation is not clear; however, the 1p21 locus is in the region of colony stimulating factor (CSF-1), which may play a role in tumorigenesis, as has been described in pigmented villonodular synovitis and tenosynovial giant cell tumor.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume194
Issue number1
DOIs
StatePublished - Oct 1 2009

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Hemangiosarcoma
Cytogenetic Analysis
Bone and Bones
Macrophage Colony-Stimulating Factor
Pigmented Villonodular Synovitis
Tibia
Chromosome Aberrations
Blood Vessels
Carcinogenesis
Mortality
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Cytogenetic analysis of a primary bone angiosarcoma. / Dunlap, Jennifer; Magenis, R. Ellen; Davis, Craig; Himoe, Eleanor; Mansoor, Atiya.

In: Cancer Genetics and Cytogenetics, Vol. 194, No. 1, 01.10.2009, p. 1-3.

Research output: Contribution to journalArticle

Dunlap, Jennifer ; Magenis, R. Ellen ; Davis, Craig ; Himoe, Eleanor ; Mansoor, Atiya. / Cytogenetic analysis of a primary bone angiosarcoma. In: Cancer Genetics and Cytogenetics. 2009 ; Vol. 194, No. 1. pp. 1-3.
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