Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor

George R. Wettach, Luke J. Boyd, Helen J. Lawce, R. Ellen Magenis, Atiya Mansoor

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature. To our knowledge, there are no previous reports on the cytogenetics of this lesion. Reported here is a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman. Subsequent cytogenetic analysis revealed a clonal reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3. This, in addition to its characteristic morphology and immunophenotype, supports the neoplastic nature of this tumor and may aid in its diagnosis.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume182
Issue number2
DOIs
StatePublished - Apr 15 2008

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Cytogenetic Analysis
Chromosomes, Human, Pair 1
Neoplasms
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 3
Subcutaneous Tissue
Cytogenetics
Foot

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Wettach, G. R., Boyd, L. J., Lawce, H. J., Magenis, R. E., & Mansoor, A. (2008). Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor. Cancer Genetics and Cytogenetics, 182(2), 140-143. https://doi.org/10.1016/j.cancergencyto.2008.01.012

Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor. / Wettach, George R.; Boyd, Luke J.; Lawce, Helen J.; Magenis, R. Ellen; Mansoor, Atiya.

In: Cancer Genetics and Cytogenetics, Vol. 182, No. 2, 15.04.2008, p. 140-143.

Research output: Contribution to journalArticle

Wettach, GR, Boyd, LJ, Lawce, HJ, Magenis, RE & Mansoor, A 2008, 'Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor', Cancer Genetics and Cytogenetics, vol. 182, no. 2, pp. 140-143. https://doi.org/10.1016/j.cancergencyto.2008.01.012
Wettach, George R. ; Boyd, Luke J. ; Lawce, Helen J. ; Magenis, R. Ellen ; Mansoor, Atiya. / Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor. In: Cancer Genetics and Cytogenetics. 2008 ; Vol. 182, No. 2. pp. 140-143.
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