Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor

George R. Wettach; Luke J. Boyd; Helen J. Lawce; R. Ellen Magenis; Atiya Mansoor

doi:10.1016/j.cancergencyto.2008.01.012

Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor

George R. Wettach, Luke J. Boyd, Helen J. Lawce, R. Ellen Magenis, Atiya Mansoor

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature. To our knowledge, there are no previous reports on the cytogenetics of this lesion. Reported here is a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman. Subsequent cytogenetic analysis revealed a clonal reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3. This, in addition to its characteristic morphology and immunophenotype, supports the neoplastic nature of this tumor and may aid in its diagnosis.

Original language	English (US)
Pages (from-to)	140-143
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	182
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2008.01.012
State	Published - Apr 15 2008
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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title = "Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor",

abstract = "Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature. To our knowledge, there are no previous reports on the cytogenetics of this lesion. Reported here is a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman. Subsequent cytogenetic analysis revealed a clonal reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3. This, in addition to its characteristic morphology and immunophenotype, supports the neoplastic nature of this tumor and may aid in its diagnosis.",

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AU - Wettach, George R.

AU - Boyd, Luke J.

AU - Lawce, Helen J.

AU - Magenis, R. Ellen

AU - Mansoor, Atiya

PY - 2008/4/15

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AB - Hemosiderotic fibrolipomatous tumor is an extremely rare, nonencapsulated, fatty lesion with a consistent histologic appearance that was originally considered reactive in nature. To our knowledge, there are no previous reports on the cytogenetics of this lesion. Reported here is a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman. Subsequent cytogenetic analysis revealed a clonal reciprocal translocation between chromosomes 1 and 10, with a further rearrangement involving this derivative chromosome 1 and chromosome 3. This, in addition to its characteristic morphology and immunophenotype, supports the neoplastic nature of this tumor and may aid in its diagnosis.

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Cytogenetic analysis of a hemosiderotic fibrolipomatous tumor

Abstract

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