Cytochrome P450 eicosanoids in cerebrovascular function and disease

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Cytochrome P450 eicosanoids play important roles in brain function and disease through their complementary actions on cell-cell communications within the neurovascular unit (NVU) and mechanisms of brain injury. Epoxy- and hydroxyeicosanoids, respectively formed by cytochrome P450 epoxygenases and ω-hydroxylases, play opposing roles in cerebrovascular function and in pathological processes underlying neural injury, including ischemia, neuroinflammation and oxidative injury. P450 eicosanoids also contribute to cerebrovascular disease risk factors, including hypertension and diabetes. We summarize studies investigating the roles P450 eicosanoids in cerebrovascular physiology and disease to highlight the existing balance between these important lipid signaling molecules, as well as their roles in maintaining neurovascular homeostasis and in acute and chronic neurovascular and neurodegenerative disorders.

Original languageEnglish (US)
JournalPharmacology and Therapeutics
DOIs
StateAccepted/In press - 2017

Keywords

  • Cerebrovascular
  • Cytochrome P450
  • EETs
  • HETEs
  • Neurovascular unit
  • SEH

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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