Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

F. P. Guengerich; P. H. Beaune; D. R. Umbenhauer; P. F. Churchill; R. W. Bork; G. A. Dannan; R. G. Knodell; R. S. Lloyd; M. V. Martin

doi:10.1042/bst0150576

Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

F. P. Guengerich, P. H. Beaune, D. R. Umbenhauer, P. F. Churchill, R. W. Bork, G. A. Dannan, R. G. Knodell, R. S. Lloyd, M. V. Martin

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Cytochrome P-450 enzymes are involved in these drug oxidations, and we are studying P-450s involved in reactions related to the polymorphisms in order to understand the roles of these enzymes in humans. We have addressed aspects of polymorphic variation in the oxidation of debrisoquine, mephenytoin, nifedipine and tolbutamide, using biochemical probes.

Original language	English (US)
Pages (from-to)	576-578
Number of pages	3
Journal	Biochemical Society transactions
Volume	15
Issue number	4
DOIs	https://doi.org/10.1042/bst0150576
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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abstract = "Cytochrome P-450 enzymes are involved in these drug oxidations, and we are studying P-450s involved in reactions related to the polymorphisms in order to understand the roles of these enzymes in humans. We have addressed aspects of polymorphic variation in the oxidation of debrisoquine, mephenytoin, nifedipine and tolbutamide, using biochemical probes.",

author = "Guengerich, {F. P.} and Beaune, {P. H.} and Umbenhauer, {D. R.} and Churchill, {P. F.} and Bork, {R. W.} and Dannan, {G. A.} and Knodell, {R. G.} and Lloyd, {R. S.} and Martin, {M. V.}",

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AU - Guengerich, F. P.

AU - Beaune, P. H.

AU - Umbenhauer, D. R.

AU - Churchill, P. F.

AU - Bork, R. W.

AU - Dannan, G. A.

AU - Knodell, R. G.

AU - Lloyd, R. S.

AU - Martin, M. V.

PY - 1987

Y1 - 1987

N2 - Cytochrome P-450 enzymes are involved in these drug oxidations, and we are studying P-450s involved in reactions related to the polymorphisms in order to understand the roles of these enzymes in humans. We have addressed aspects of polymorphic variation in the oxidation of debrisoquine, mephenytoin, nifedipine and tolbutamide, using biochemical probes.

AB - Cytochrome P-450 enzymes are involved in these drug oxidations, and we are studying P-450s involved in reactions related to the polymorphisms in order to understand the roles of these enzymes in humans. We have addressed aspects of polymorphic variation in the oxidation of debrisoquine, mephenytoin, nifedipine and tolbutamide, using biochemical probes.

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JO - Biochemical Society transactions

JF - Biochemical Society transactions

IS - 4

ER -

Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

Abstract

ASJC Scopus subject areas

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