Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

F. P. Guengerich, P. H. Beaune, D. R. Umbenhauer, P. F. Churchill, R. W. Bork, G. A. Dannan, R. G. Knodell, R. S. Lloyd, M. V. Martin

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16 Scopus citations

Abstract

Cytochrome P-450 enzymes are involved in these drug oxidations, and we are studying P-450s involved in reactions related to the polymorphisms in order to understand the roles of these enzymes in humans. We have addressed aspects of polymorphic variation in the oxidation of debrisoquine, mephenytoin, nifedipine and tolbutamide, using biochemical probes.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalBiochemical Society transactions
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Biochemistry

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    Guengerich, F. P., Beaune, P. H., Umbenhauer, D. R., Churchill, P. F., Bork, R. W., Dannan, G. A., Knodell, R. G., Lloyd, R. S., & Martin, M. V. (1987). Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. Biochemical Society transactions, 15(4), 576-578. https://doi.org/10.1042/bst0150576