Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans

F. P. Guengerich, P. H. Beaune, D. R. Umbenhauer, P. F. Churchill, R. W. Bork, G. A. Dannan, R. G. Knodell, Robert (Stephen) Lloyd, M. V. Martin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cytochrome P-450 enzymes are involved in these drug oxidations, and we are studying P-450s involved in reactions related to the polymorphisms in order to understand the roles of these enzymes in humans. We have addressed aspects of polymorphic variation in the oxidation of debrisoquine, mephenytoin, nifedipine and tolbutamide, using biochemical probes.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalBiochemical Society Transactions
Volume15
Issue number4
StatePublished - 1987
Externally publishedYes

Fingerprint

Mephenytoin
Debrisoquin
Tolbutamide
Genetic Polymorphisms
Nifedipine
Polymorphism
Cytochrome P-450 Enzyme System
Oxidation
Enzymes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry

Cite this

Guengerich, F. P., Beaune, P. H., Umbenhauer, D. R., Churchill, P. F., Bork, R. W., Dannan, G. A., ... Martin, M. V. (1987). Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. Biochemical Society Transactions, 15(4), 576-578.

Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. / Guengerich, F. P.; Beaune, P. H.; Umbenhauer, D. R.; Churchill, P. F.; Bork, R. W.; Dannan, G. A.; Knodell, R. G.; Lloyd, Robert (Stephen); Martin, M. V.

In: Biochemical Society Transactions, Vol. 15, No. 4, 1987, p. 576-578.

Research output: Contribution to journalArticle

Guengerich, FP, Beaune, PH, Umbenhauer, DR, Churchill, PF, Bork, RW, Dannan, GA, Knodell, RG, Lloyd, RS & Martin, MV 1987, 'Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans', Biochemical Society Transactions, vol. 15, no. 4, pp. 576-578.
Guengerich FP, Beaune PH, Umbenhauer DR, Churchill PF, Bork RW, Dannan GA et al. Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. Biochemical Society Transactions. 1987;15(4):576-578.
Guengerich, F. P. ; Beaune, P. H. ; Umbenhauer, D. R. ; Churchill, P. F. ; Bork, R. W. ; Dannan, G. A. ; Knodell, R. G. ; Lloyd, Robert (Stephen) ; Martin, M. V. / Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. In: Biochemical Society Transactions. 1987 ; Vol. 15, No. 4. pp. 576-578.
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