Cystatin C and frailty in older men

Allyson Hart, Misti L. Paudel, Brent C. Taylor, Areef Ishani, Eric Orwoll, Peggy M. Cawthon, Kristine E. Ensrud

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives To determine whether higher cystatin C would be associated with greater frailty in men aged 65 and older. Design Cross-sectional cohort study. Setting Six U.S. sites. Participants A random sample of community-dwelling men aged 65 and older enrolled in the Osteoporotic Fractures in Men (MrOS) Study (mean age 73.8; 9.8% frail and 47.2% intermediate frailty; N = 1,602). Measurements Serum cystatin C, creatinine, and frailty were measured. Frailty was analyzed as an ordinal outcome of robust, intermediate frailty, and frail using a multinomial logistic regression model, and the base model was adjusted for age, race, and clinical site. Results Higher cystatin C was associated with seven times greater odds of being frail than being robust (odds ratio (OR) quartile 4 vs 1 = 7.12, 95% confidence interval (CI) = 3.76-13.46) and 2.4 times greater odds of intermediate frailty than robust (OR quartile 4 vs 1 = 2.38, 95% CI = 1.70-3.32). The association was attenuated but persisted after adjusting for multiple possible confounders. In contrast, neither higher serum creatinine (OR quartile 4 vs 1 = 1.36, 95% CI = 0.78-2.40) nor lower creatinine-based estimated glomerular filtration rate (OR quartile 4 vs 1 = 1.01, 95% CI = 0.54-1.87) was associated in a graded manner with greater odds of frailty. Conclusion Higher cystatin C, but not creatinine-based measures, was associated with greater odds of frailty in this cohort of older men.

Original languageEnglish (US)
Pages (from-to)1530-1536
Number of pages7
JournalJournal of the American Geriatrics Society
Volume61
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Cystatin C
Creatinine
Odds Ratio
Confidence Intervals
Logistic Models
Independent Living
Osteoporotic Fractures
Serum
Glomerular Filtration Rate
Cohort Studies
Cross-Sectional Studies

Keywords

  • creatinine
  • cystatin C
  • elderly
  • frailty
  • kidney function

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Hart, A., Paudel, M. L., Taylor, B. C., Ishani, A., Orwoll, E., Cawthon, P. M., & Ensrud, K. E. (2013). Cystatin C and frailty in older men. Journal of the American Geriatrics Society, 61(9), 1530-1536. https://doi.org/10.1111/jgs.12413

Cystatin C and frailty in older men. / Hart, Allyson; Paudel, Misti L.; Taylor, Brent C.; Ishani, Areef; Orwoll, Eric; Cawthon, Peggy M.; Ensrud, Kristine E.

In: Journal of the American Geriatrics Society, Vol. 61, No. 9, 09.2013, p. 1530-1536.

Research output: Contribution to journalArticle

Hart, A, Paudel, ML, Taylor, BC, Ishani, A, Orwoll, E, Cawthon, PM & Ensrud, KE 2013, 'Cystatin C and frailty in older men', Journal of the American Geriatrics Society, vol. 61, no. 9, pp. 1530-1536. https://doi.org/10.1111/jgs.12413
Hart A, Paudel ML, Taylor BC, Ishani A, Orwoll E, Cawthon PM et al. Cystatin C and frailty in older men. Journal of the American Geriatrics Society. 2013 Sep;61(9):1530-1536. https://doi.org/10.1111/jgs.12413
Hart, Allyson ; Paudel, Misti L. ; Taylor, Brent C. ; Ishani, Areef ; Orwoll, Eric ; Cawthon, Peggy M. ; Ensrud, Kristine E. / Cystatin C and frailty in older men. In: Journal of the American Geriatrics Society. 2013 ; Vol. 61, No. 9. pp. 1530-1536.
@article{4805e5e4c8b0402aafb4f13c84007e23,
title = "Cystatin C and frailty in older men",
abstract = "Objectives To determine whether higher cystatin C would be associated with greater frailty in men aged 65 and older. Design Cross-sectional cohort study. Setting Six U.S. sites. Participants A random sample of community-dwelling men aged 65 and older enrolled in the Osteoporotic Fractures in Men (MrOS) Study (mean age 73.8; 9.8{\%} frail and 47.2{\%} intermediate frailty; N = 1,602). Measurements Serum cystatin C, creatinine, and frailty were measured. Frailty was analyzed as an ordinal outcome of robust, intermediate frailty, and frail using a multinomial logistic regression model, and the base model was adjusted for age, race, and clinical site. Results Higher cystatin C was associated with seven times greater odds of being frail than being robust (odds ratio (OR) quartile 4 vs 1 = 7.12, 95{\%} confidence interval (CI) = 3.76-13.46) and 2.4 times greater odds of intermediate frailty than robust (OR quartile 4 vs 1 = 2.38, 95{\%} CI = 1.70-3.32). The association was attenuated but persisted after adjusting for multiple possible confounders. In contrast, neither higher serum creatinine (OR quartile 4 vs 1 = 1.36, 95{\%} CI = 0.78-2.40) nor lower creatinine-based estimated glomerular filtration rate (OR quartile 4 vs 1 = 1.01, 95{\%} CI = 0.54-1.87) was associated in a graded manner with greater odds of frailty. Conclusion Higher cystatin C, but not creatinine-based measures, was associated with greater odds of frailty in this cohort of older men.",
keywords = "creatinine, cystatin C, elderly, frailty, kidney function",
author = "Allyson Hart and Paudel, {Misti L.} and Taylor, {Brent C.} and Areef Ishani and Eric Orwoll and Cawthon, {Peggy M.} and Ensrud, {Kristine E.}",
year = "2013",
month = "9",
doi = "10.1111/jgs.12413",
language = "English (US)",
volume = "61",
pages = "1530--1536",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Cystatin C and frailty in older men

AU - Hart, Allyson

AU - Paudel, Misti L.

AU - Taylor, Brent C.

AU - Ishani, Areef

AU - Orwoll, Eric

AU - Cawthon, Peggy M.

AU - Ensrud, Kristine E.

PY - 2013/9

Y1 - 2013/9

N2 - Objectives To determine whether higher cystatin C would be associated with greater frailty in men aged 65 and older. Design Cross-sectional cohort study. Setting Six U.S. sites. Participants A random sample of community-dwelling men aged 65 and older enrolled in the Osteoporotic Fractures in Men (MrOS) Study (mean age 73.8; 9.8% frail and 47.2% intermediate frailty; N = 1,602). Measurements Serum cystatin C, creatinine, and frailty were measured. Frailty was analyzed as an ordinal outcome of robust, intermediate frailty, and frail using a multinomial logistic regression model, and the base model was adjusted for age, race, and clinical site. Results Higher cystatin C was associated with seven times greater odds of being frail than being robust (odds ratio (OR) quartile 4 vs 1 = 7.12, 95% confidence interval (CI) = 3.76-13.46) and 2.4 times greater odds of intermediate frailty than robust (OR quartile 4 vs 1 = 2.38, 95% CI = 1.70-3.32). The association was attenuated but persisted after adjusting for multiple possible confounders. In contrast, neither higher serum creatinine (OR quartile 4 vs 1 = 1.36, 95% CI = 0.78-2.40) nor lower creatinine-based estimated glomerular filtration rate (OR quartile 4 vs 1 = 1.01, 95% CI = 0.54-1.87) was associated in a graded manner with greater odds of frailty. Conclusion Higher cystatin C, but not creatinine-based measures, was associated with greater odds of frailty in this cohort of older men.

AB - Objectives To determine whether higher cystatin C would be associated with greater frailty in men aged 65 and older. Design Cross-sectional cohort study. Setting Six U.S. sites. Participants A random sample of community-dwelling men aged 65 and older enrolled in the Osteoporotic Fractures in Men (MrOS) Study (mean age 73.8; 9.8% frail and 47.2% intermediate frailty; N = 1,602). Measurements Serum cystatin C, creatinine, and frailty were measured. Frailty was analyzed as an ordinal outcome of robust, intermediate frailty, and frail using a multinomial logistic regression model, and the base model was adjusted for age, race, and clinical site. Results Higher cystatin C was associated with seven times greater odds of being frail than being robust (odds ratio (OR) quartile 4 vs 1 = 7.12, 95% confidence interval (CI) = 3.76-13.46) and 2.4 times greater odds of intermediate frailty than robust (OR quartile 4 vs 1 = 2.38, 95% CI = 1.70-3.32). The association was attenuated but persisted after adjusting for multiple possible confounders. In contrast, neither higher serum creatinine (OR quartile 4 vs 1 = 1.36, 95% CI = 0.78-2.40) nor lower creatinine-based estimated glomerular filtration rate (OR quartile 4 vs 1 = 1.01, 95% CI = 0.54-1.87) was associated in a graded manner with greater odds of frailty. Conclusion Higher cystatin C, but not creatinine-based measures, was associated with greater odds of frailty in this cohort of older men.

KW - creatinine

KW - cystatin C

KW - elderly

KW - frailty

KW - kidney function

UR - http://www.scopus.com/inward/record.url?scp=84884284151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884284151&partnerID=8YFLogxK

U2 - 10.1111/jgs.12413

DO - 10.1111/jgs.12413

M3 - Article

C2 - 24001352

AN - SCOPUS:84884284151

VL - 61

SP - 1530

EP - 1536

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 9

ER -