Cyclosporine nephrotoxicity

Emmanuel A. Burdmann; Takeshi F. Andoh; Luis Yu; William M. Bennett

doi:10.1016/S0270-9295(03)00090-1

Cyclosporine nephrotoxicity

Emmanuel A. Burdmann, Takeshi F. Andoh, Luis Yu, William M. Bennett

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Article › peer-review

244 Scopus citations

Abstract

After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

Original language	English (US)
Pages (from-to)	465-476
Number of pages	12
Journal	Seminars in nephrology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/S0270-9295(03)00090-1
State	Published - Sep 2003

ASJC Scopus subject areas

Nephrology

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10.1016/S0270-9295(03)00090-1

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title = "Cyclosporine nephrotoxicity",

abstract = "After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.",

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T1 - Cyclosporine nephrotoxicity

AU - Burdmann, Emmanuel A.

AU - Andoh, Takeshi F.

AU - Yu, Luis

AU - Bennett, William M.

PY - 2003/9

Y1 - 2003/9

N2 - After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

AB - After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical problem. Cyclosporine-induced renal injury has been described in solid organs recipients and in patients treated for autoimmune diseases. It is manifested in 2 distinct and well characterized forms, acute nephrotoxicity and chronic nephrotoxicity. This communication reviews the current literature analyzing the available data about the pathogenesis and mechanisms of acute and chronic cyclosporine-induced nephrotoxicity. A working hypothesis for the possible mechanisms of chronic cyclosporine nephrotoxicity will be provided.

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U2 - 10.1016/S0270-9295(03)00090-1

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AN - SCOPUS:0141869674

SN - 0270-9295

VL - 23

SP - 465

EP - 476

JO - Seminars in nephrology

JF - Seminars in nephrology

IS - 5

ER -

Cyclosporine nephrotoxicity

Abstract

ASJC Scopus subject areas

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