Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report

S. T. Bigos, B. C. Nisula, G. H. Daniels, R. C. Eastman, H. H. Johnston, Peter Kohler

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Three patients with advanced Graves' ophthalmopathy were treated with cyclophosphamide. All had proptosis and diplopia. One patient had disabling iatrogenic Cushing's syndrome from steroid treatment of the ophthalmopathy and had undergone bilateral orbital decompression before cyclophosphamide therapy; steroids could not subsequently be withdrawn. When cyclophosphamide was administered to the cushingoid patient, withdrawal of glucocorticoid therapy was then possible. Diplopia completely resolved in two patients and improved in the third coincident with administration of cyclophosphamide. Deteriorating visual acuity resolved in one patient. Chemosis improved in the two affected patients. Proptosis was unchanged in all three patients. Cyclophosphamide deserves further study as a therapeutic agent in Graves' disease.

Original languageEnglish (US)
Pages (from-to)921-923
Number of pages3
JournalAnnals of Internal Medicine
Volume90
Issue number6
StatePublished - 1979
Externally publishedYes

Fingerprint

Graves Ophthalmopathy
Cyclophosphamide
Exophthalmos
Diplopia
Steroids
Cushing Syndrome
Graves Disease
Therapeutics
Decompression
Glucocorticoids
Visual Acuity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bigos, S. T., Nisula, B. C., Daniels, G. H., Eastman, R. C., Johnston, H. H., & Kohler, P. (1979). Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report. Annals of Internal Medicine, 90(6), 921-923.

Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report. / Bigos, S. T.; Nisula, B. C.; Daniels, G. H.; Eastman, R. C.; Johnston, H. H.; Kohler, Peter.

In: Annals of Internal Medicine, Vol. 90, No. 6, 1979, p. 921-923.

Research output: Contribution to journalArticle

Bigos, ST, Nisula, BC, Daniels, GH, Eastman, RC, Johnston, HH & Kohler, P 1979, 'Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report', Annals of Internal Medicine, vol. 90, no. 6, pp. 921-923.
Bigos, S. T. ; Nisula, B. C. ; Daniels, G. H. ; Eastman, R. C. ; Johnston, H. H. ; Kohler, Peter. / Cyclophosphamide in the management of advanced Graves' ophthalmopathy. A preliminary report. In: Annals of Internal Medicine. 1979 ; Vol. 90, No. 6. pp. 921-923.
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