Cyclooxygenase-2 expression and function in renal pathophysiology

Radko Komers, Murray Epstein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cyclooxygenase (COX) constitutes the rate-limiting enzyme in the biosynthetic cascade of prostaglandin (PG). Evidence has accrued suggesting pathophysiological states with altered COX-2 activity and expression. Recent experimental evidence suggests that COX-2 has a pathogenetic role in some of these derangements. In other situations, the effect of altered COX-2 regulation is unclear or possibly beneficial. These processes suggest new areas for potential use of COX-2-specific inhibitors. Conversely, in some conditions COX-2-specific inhibitors should be avoided. The conventional view is that COX-2 is an inducible enzyme. However, COX-2 is also active in the constitutive production of prostanoids in the kidney. Consequently, the pathophysiological states discussed herein include not only COX-2 induction during inflammation but also derangements in COX-2 expression and function caused by non-inflammatory stimuli.

Original languageEnglish (US)
JournalJournal of Hypertension
Volume20
Issue numberSUPPL. 6
DOIs
StatePublished - Sep 2002

Fingerprint

Cyclooxygenase 2
Kidney
Cyclooxygenase 2 Inhibitors
Prostaglandins
Enzymes
Prostaglandin-Endoperoxide Synthases
Inflammation

Keywords

  • Cyclooxygenase-2
  • Diabetic nephropathy
  • Glomerulonephritis
  • Hypertension
  • Renal
  • Renin

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Cyclooxygenase-2 expression and function in renal pathophysiology. / Komers, Radko; Epstein, Murray.

In: Journal of Hypertension, Vol. 20, No. SUPPL. 6, 09.2002.

Research output: Contribution to journalArticle

Komers, Radko ; Epstein, Murray. / Cyclooxygenase-2 expression and function in renal pathophysiology. In: Journal of Hypertension. 2002 ; Vol. 20, No. SUPPL. 6.
@article{7a823e69848b462e93839308f6596fd1,
title = "Cyclooxygenase-2 expression and function in renal pathophysiology",
abstract = "Cyclooxygenase (COX) constitutes the rate-limiting enzyme in the biosynthetic cascade of prostaglandin (PG). Evidence has accrued suggesting pathophysiological states with altered COX-2 activity and expression. Recent experimental evidence suggests that COX-2 has a pathogenetic role in some of these derangements. In other situations, the effect of altered COX-2 regulation is unclear or possibly beneficial. These processes suggest new areas for potential use of COX-2-specific inhibitors. Conversely, in some conditions COX-2-specific inhibitors should be avoided. The conventional view is that COX-2 is an inducible enzyme. However, COX-2 is also active in the constitutive production of prostanoids in the kidney. Consequently, the pathophysiological states discussed herein include not only COX-2 induction during inflammation but also derangements in COX-2 expression and function caused by non-inflammatory stimuli.",
keywords = "Cyclooxygenase-2, Diabetic nephropathy, Glomerulonephritis, Hypertension, Renal, Renin",
author = "Radko Komers and Murray Epstein",
year = "2002",
month = "9",
doi = "10.1097/00004872-200212000-00001",
language = "English (US)",
volume = "20",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 6",

}

TY - JOUR

T1 - Cyclooxygenase-2 expression and function in renal pathophysiology

AU - Komers, Radko

AU - Epstein, Murray

PY - 2002/9

Y1 - 2002/9

N2 - Cyclooxygenase (COX) constitutes the rate-limiting enzyme in the biosynthetic cascade of prostaglandin (PG). Evidence has accrued suggesting pathophysiological states with altered COX-2 activity and expression. Recent experimental evidence suggests that COX-2 has a pathogenetic role in some of these derangements. In other situations, the effect of altered COX-2 regulation is unclear or possibly beneficial. These processes suggest new areas for potential use of COX-2-specific inhibitors. Conversely, in some conditions COX-2-specific inhibitors should be avoided. The conventional view is that COX-2 is an inducible enzyme. However, COX-2 is also active in the constitutive production of prostanoids in the kidney. Consequently, the pathophysiological states discussed herein include not only COX-2 induction during inflammation but also derangements in COX-2 expression and function caused by non-inflammatory stimuli.

AB - Cyclooxygenase (COX) constitutes the rate-limiting enzyme in the biosynthetic cascade of prostaglandin (PG). Evidence has accrued suggesting pathophysiological states with altered COX-2 activity and expression. Recent experimental evidence suggests that COX-2 has a pathogenetic role in some of these derangements. In other situations, the effect of altered COX-2 regulation is unclear or possibly beneficial. These processes suggest new areas for potential use of COX-2-specific inhibitors. Conversely, in some conditions COX-2-specific inhibitors should be avoided. The conventional view is that COX-2 is an inducible enzyme. However, COX-2 is also active in the constitutive production of prostanoids in the kidney. Consequently, the pathophysiological states discussed herein include not only COX-2 induction during inflammation but also derangements in COX-2 expression and function caused by non-inflammatory stimuli.

KW - Cyclooxygenase-2

KW - Diabetic nephropathy

KW - Glomerulonephritis

KW - Hypertension

KW - Renal

KW - Renin

UR - http://www.scopus.com/inward/record.url?scp=0036764484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036764484&partnerID=8YFLogxK

U2 - 10.1097/00004872-200212000-00001

DO - 10.1097/00004872-200212000-00001

M3 - Article

C2 - 12683422

AN - SCOPUS:0036764484

VL - 20

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - SUPPL. 6

ER -