Cyclooxygenase-2 expression and function in renal pathophysiology

Radko Komers, Murray Epstein

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Cyclooxygenase (COX) constitutes the rate-limiting enzyme in the biosynthetic cascade of prostaglandin (PG). Evidence has accrued suggesting pathophysiological states with altered COX-2 activity and expression. Recent experimental evidence suggests that COX-2 has a pathogenetic role in some of these derangements. In other situations, the effect of altered COX-2 regulation is unclear or possibly beneficial. These processes suggest new areas for potential use of COX-2-specific inhibitors. Conversely, in some conditions COX-2-specific inhibitors should be avoided. The conventional view is that COX-2 is an inducible enzyme. However, COX-2 is also active in the constitutive production of prostanoids in the kidney. Consequently, the pathophysiological states discussed herein include not only COX-2 induction during inflammation but also derangements in COX-2 expression and function caused by non-inflammatory stimuli.

Original languageEnglish (US)
Pages (from-to)S11-S15
JournalJournal of Hypertension
Volume20
Issue numberSUPPL. 6
DOIs
StatePublished - Sep 2002

Keywords

  • Cyclooxygenase-2
  • Diabetic nephropathy
  • Glomerulonephritis
  • Hypertension
  • Renal
  • Renin

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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