Cyclic GMP and cyclic AMP levels in median eminence, hypothalamus and pituitary gland of the rat after decapitation or microwave irradiation

Z. Naor, Sergio Ojeda, A. Negro-Vilar, S. M. McCann

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cyclic AMP and cyclic GMP content of the median eminence (ME), medial basal hypothalamus (MBH), posterior pituitary (PP) and anterior pituitary (AP) of inact male rats was measured by radioimmunoassay following decapitation or exposure to microwave irradiation (MW). Levels of both nucleotides in MW irradiated animals were higher in all three nervous tissues studied than in the AP. Following decapitation cyclicAMP levels increased strikingly in the MBH and ME, slightly in the AP, but remained unchanged in the PP. Cyclic GMP levels increased more markedly in the ME than in the MBH, slightly in the PP and did not change in the AP. The distinct synthesizing capability of the cyclic AMP and cyclic GMP generating systems in the ME, a region rich in neurohormones known to control anterior pituitary function, raises the possibility that these nucleotides are involved in the process of neurohormone secretion by the ME.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalNeuroscience Letters
Volume13
Issue number2
DOIs
StatePublished - 1979
Externally publishedYes

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Decapitation
Median Eminence
Pituitary Gland
Microwaves
Cyclic AMP
Hypothalamus
Middle Hypothalamus
Cyclic GMP
Neurotransmitter Agents
Nucleotides
Nerve Tissue
Secretory Pathway
Radioimmunoassay
cyclic guanosine monophosphate-adenosine monophosphate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cyclic GMP and cyclic AMP levels in median eminence, hypothalamus and pituitary gland of the rat after decapitation or microwave irradiation. / Naor, Z.; Ojeda, Sergio; Negro-Vilar, A.; McCann, S. M.

In: Neuroscience Letters, Vol. 13, No. 2, 1979, p. 189-194.

Research output: Contribution to journalArticle

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