Cutting edge: Identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation

Hugo R. Rosen, David J. Hinrichs, Rachel L. Leistikow, Glenda Callender, Anne M. Wertheimer, Michael I. Nishimura, David Lewinsohn

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

By necessity, human liver transplantation is performed across HLA barriers. As a result, intracellular infection of the allograft presents a unique immunologic challenge for the recipient's immune system. In this study, we describe the presence of HLA-A2-restricted, hepatitis C virus (HCV)-specific CD8+ T cells in liver transplant recipients in whom the allograft is HLA-A2 positive and the recipient is HLA-A2 negative. These memory-effector T cells are recipient derived and recognize HCV peptide uniquely in the context of HLA-A2. Furthermore, these cells were absent before the transplant, suggesting that the allograft is capable of selectively expanding naive CD8+ T cells. The in vitro specificity to donor HLA allele-restricted CD8+ T cells suggests that these cells may function to control HCV spread in the allograft.

Original languageEnglish (US)
Pages (from-to)5355-5359
Number of pages5
JournalJournal of Immunology
Volume173
Issue number9
StatePublished - Nov 1 2004

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HLA-A2 Antigen
Hepacivirus
Liver Transplantation
Allografts
Alleles
Tissue Donors
T-Lymphocytes
Immune System
Transplants
Peptides
Liver
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Rosen, H. R., Hinrichs, D. J., Leistikow, R. L., Callender, G., Wertheimer, A. M., Nishimura, M. I., & Lewinsohn, D. (2004). Cutting edge: Identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. Journal of Immunology, 173(9), 5355-5359.

Cutting edge : Identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. / Rosen, Hugo R.; Hinrichs, David J.; Leistikow, Rachel L.; Callender, Glenda; Wertheimer, Anne M.; Nishimura, Michael I.; Lewinsohn, David.

In: Journal of Immunology, Vol. 173, No. 9, 01.11.2004, p. 5355-5359.

Research output: Contribution to journalArticle

Rosen, HR, Hinrichs, DJ, Leistikow, RL, Callender, G, Wertheimer, AM, Nishimura, MI & Lewinsohn, D 2004, 'Cutting edge: Identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation', Journal of Immunology, vol. 173, no. 9, pp. 5355-5359.
Rosen HR, Hinrichs DJ, Leistikow RL, Callender G, Wertheimer AM, Nishimura MI et al. Cutting edge: Identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. Journal of Immunology. 2004 Nov 1;173(9):5355-5359.
Rosen, Hugo R. ; Hinrichs, David J. ; Leistikow, Rachel L. ; Callender, Glenda ; Wertheimer, Anne M. ; Nishimura, Michael I. ; Lewinsohn, David. / Cutting edge : Identification of hepatitis C virus-specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. In: Journal of Immunology. 2004 ; Vol. 173, No. 9. pp. 5355-5359.
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