TY - JOUR
T1 - Cutting edge
T2 - Expression of chemokine receptor CXCR1 on human effector CD8+ T cells
AU - Takata, Hiroshi
AU - Tomiyama, Hiroko
AU - Fujiwara, Mamoru
AU - Kobayashi, Naoki
AU - Takiguchi, Masafumi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2004/8/15
Y1 - 2004/8/15
N2 - IL-8 is a potent inflammatory cytokine that induces chemotaxis of neutrophils expressing CXCR1 and CXCR2, thus indicating its involvement in the migration of these cells to inflammatory sites where bacteria proliferate. Presently, we showed that CXCR1+ cells were predominantly found among CD8+ T cells having effector phenotype, and that the expression of CXCR1 was positively correlated with that of perforin, suggesting that CXCR1 is expressed on effector CD8+ T cells. Indeed, human CMV-specific CD8+ T cells from healthy individuals, which mostly express the effector phenotype and have cytolytic function, expressed CXCR1, whereas EBV-specific CD8+ T cells, which mostly express the memory phenotype and have no cytolytic function, did not express this receptor. The results of a chemotaxis assay showed that the migration of CXCR1+CD8+ T cells was induced by IL-8. These results suggest that the IL-8-CXCR1 pathway plays an important role in the homing of effector CD8+ T cells.
AB - IL-8 is a potent inflammatory cytokine that induces chemotaxis of neutrophils expressing CXCR1 and CXCR2, thus indicating its involvement in the migration of these cells to inflammatory sites where bacteria proliferate. Presently, we showed that CXCR1+ cells were predominantly found among CD8+ T cells having effector phenotype, and that the expression of CXCR1 was positively correlated with that of perforin, suggesting that CXCR1 is expressed on effector CD8+ T cells. Indeed, human CMV-specific CD8+ T cells from healthy individuals, which mostly express the effector phenotype and have cytolytic function, expressed CXCR1, whereas EBV-specific CD8+ T cells, which mostly express the memory phenotype and have no cytolytic function, did not express this receptor. The results of a chemotaxis assay showed that the migration of CXCR1+CD8+ T cells was induced by IL-8. These results suggest that the IL-8-CXCR1 pathway plays an important role in the homing of effector CD8+ T cells.
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U2 - 10.4049/jimmunol.173.4.2231
DO - 10.4049/jimmunol.173.4.2231
M3 - Article
C2 - 15294933
AN - SCOPUS:4043162042
SN - 0022-1767
VL - 173
SP - 2231
EP - 2235
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -