Cutting edge

Estrogen drives expiansion of the CD4+CD25 + regulatory T cell compartment

Magdalena J. Polanczyk, Bryan D. Carson, Sandhya Subramanian, Michael Afentoulis, Arthur Vandenbark, Steven F. Ziegler, Halina Offner

Research output: Contribution to journalArticle

321 Citations (Scopus)

Abstract

CD4+CD25+ regulatory T cells are crucial to the maintenance of tolerance in normal individuals. However, the factors regulating this cell population and its function are largely unknown. Estrogen has been shown to protect against the development of autoimmune disease, yet the mechanism is not known. We demonstrate that estrogen (I 7-β-estradiol, E2) is capable of augmenting FoxP3 expression in vitro and in vivo. Treatment of naive mice with E2 increased both CD25+ cell number and FoxP3 expression level. Further, the ability of E2 to protect against autoimmune disease (experimental autoimmune encephalomyelitis) correlated with its ability to up-regulate FoxP3, as both were reduced in estrogen receptor α-deficient animals. Finally, E2 treatment and pregnancy induced FoxP3 protein expression to a similar degree, suggesting that high estrogen levels during pregnancy may help to maintain fetal tolerance. In summary, our data suggest E2 promotes tolerance by expanding the regulatory T cell compartment.

Original languageEnglish (US)
Pages (from-to)2227-2230
Number of pages4
JournalJournal of Immunology
Volume173
Issue number4
StatePublished - Aug 15 2004

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Regulatory T-Lymphocytes
Estrogens
Autoimmune Diseases
Pregnancy
Autoimmune Experimental Encephalomyelitis
Estrogen Receptors
Estradiol
Up-Regulation
Cell Count
Maintenance
Population
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Polanczyk, M. J., Carson, B. D., Subramanian, S., Afentoulis, M., Vandenbark, A., Ziegler, S. F., & Offner, H. (2004). Cutting edge: Estrogen drives expiansion of the CD4+CD25 + regulatory T cell compartment. Journal of Immunology, 173(4), 2227-2230.

Cutting edge : Estrogen drives expiansion of the CD4+CD25 + regulatory T cell compartment. / Polanczyk, Magdalena J.; Carson, Bryan D.; Subramanian, Sandhya; Afentoulis, Michael; Vandenbark, Arthur; Ziegler, Steven F.; Offner, Halina.

In: Journal of Immunology, Vol. 173, No. 4, 15.08.2004, p. 2227-2230.

Research output: Contribution to journalArticle

Polanczyk, MJ, Carson, BD, Subramanian, S, Afentoulis, M, Vandenbark, A, Ziegler, SF & Offner, H 2004, 'Cutting edge: Estrogen drives expiansion of the CD4+CD25 + regulatory T cell compartment', Journal of Immunology, vol. 173, no. 4, pp. 2227-2230.
Polanczyk MJ, Carson BD, Subramanian S, Afentoulis M, Vandenbark A, Ziegler SF et al. Cutting edge: Estrogen drives expiansion of the CD4+CD25 + regulatory T cell compartment. Journal of Immunology. 2004 Aug 15;173(4):2227-2230.
Polanczyk, Magdalena J. ; Carson, Bryan D. ; Subramanian, Sandhya ; Afentoulis, Michael ; Vandenbark, Arthur ; Ziegler, Steven F. ; Offner, Halina. / Cutting edge : Estrogen drives expiansion of the CD4+CD25 + regulatory T cell compartment. In: Journal of Immunology. 2004 ; Vol. 173, No. 4. pp. 2227-2230.
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