Cutting edge: Decreased accumulation and regulatory function of CD4 +CD25high T cells in human STAT5b deficiency

Aileen C. Cohen, Kari C. Nadeau, Wenwei Tu, Vivian Hwa, Kira Dionis, Liliana Bezrodnik, Alejandro Teper, Maria Gaillard, Juan Heinrich, Alan M. Krensky, Ron G. Rosenfeld, David B. Lewis

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

We show that STAT5b is important for the in vivo accumulation of CD4 +CD25high T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4+CD25high T cells. STAT5b A630P/A630P CD4+CD25high T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4+CD25- T cells. Expression of CD25, a component of the high-affinity IL-2R, was also reduced in response to IL-2 or after in vitro propagation. The impact of the STAT5b mutation was selective in that IL-2-mediated up-regulation of the common γ-chain cytokine receptor and perform, and activation-induced expressions of CD154 and IFN-γ were normal. These results indicate that STAT5b propagates an important IL-2-mediated signal for the in vivo accumulation of functional regulatory T cells.

Original languageEnglish (US)
Pages (from-to)2770-2774
Number of pages5
JournalJournal of Immunology
Volume177
Issue number5
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Cohen, A. C., Nadeau, K. C., Tu, W., Hwa, V., Dionis, K., Bezrodnik, L., Teper, A., Gaillard, M., Heinrich, J., Krensky, A. M., Rosenfeld, R. G., & Lewis, D. B. (2006). Cutting edge: Decreased accumulation and regulatory function of CD4 +CD25high T cells in human STAT5b deficiency. Journal of Immunology, 177(5), 2770-2774. https://doi.org/10.4049/jimmunol.177.5.2770