Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells

Henri Alexandre Michaud, Devi SenGupta, Miguel De Mulder, Steven G. Deeks, Jeffrey N. Martin, James J. Kobie, Jonah Sacha, Douglas F. Nixon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The failure of antiviral vaccines is often associated with rapid viral escape from specific immune responses. In the past, conserved epitope or algorithmic epitope selections, such as mosaic vaccines, have been designed to diversify immunity and to circumvent potential viral escape. An alternative approach is to identify conserved stable non-HIV-1 self-epitopes present exclusively in HIV-1-infected cells. We showed previously that human endogenous retroviral (HERV) mRNA transcripts and protein are found in cells of HIV-1-infected patients and that HERV-K (HML-2)-specific T cells can eliminate HIV-1-infected cells in vitro. In this article, we demonstrate that a human anti-HERV-K (HML-2) transmembrane protein Ab binds specifically to HIV- 1-infected cells and eliminates them through an Abdependent cellular cytotoxicity mechanism in vitro. Thus, Abs directed against epitopes other than HIV-1 proteins may have a role in eliminating HIV-1-infected cells and could be targeted in novel vaccine approaches or immunotherapeutic modalities.

Original languageEnglish (US)
Pages (from-to)1544-1548
Number of pages5
JournalJournal of Immunology
Volume193
Issue number4
DOIs
StatePublished - Aug 15 2014

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HIV-1
Glycoproteins
Viruses
Antibodies
Epitopes
Vaccines
Human Immunodeficiency Virus Proteins
Antiviral Agents
Immunity
Proteins
T-Lymphocytes
Messenger RNA
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells. / Michaud, Henri Alexandre; SenGupta, Devi; De Mulder, Miguel; Deeks, Steven G.; Martin, Jeffrey N.; Kobie, James J.; Sacha, Jonah; Nixon, Douglas F.

In: Journal of Immunology, Vol. 193, No. 4, 15.08.2014, p. 1544-1548.

Research output: Contribution to journalArticle

Michaud, Henri Alexandre ; SenGupta, Devi ; De Mulder, Miguel ; Deeks, Steven G. ; Martin, Jeffrey N. ; Kobie, James J. ; Sacha, Jonah ; Nixon, Douglas F. / Cutting edge : An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells. In: Journal of Immunology. 2014 ; Vol. 193, No. 4. pp. 1544-1548.
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