Cutaneous secondary syphilis: Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis

M. C. McNeely, J. L. Jorizzo, Alvin Jr Solomon, E. B. Smith, T. Cavallo, R. L. Sanchez

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A circulating immune complex-mediated pathogenesis for lesions of secondary syphilis has been postulated. Textbook descriptions of a lymphoplasmacytic histopathologic picture have contradicted a role for circulating immune complexes in lesion pathogenesis. Four patients with early cutaneous lesions of secondary syphilis were studied. All four patients had serum Raji cell and/or Clq binding assay evidence for circulating immune complexes. Three patients showed a neutrophilic vascular reaction on histologic study of early lesions. The patients studied had immunofluorescence microscopic evidence of immunoreactant deposition in dermal blood vessels (4 hours) and/or a neutrophilic vascular reaction (24 hours) after intradermal histamine injection. Dieterle staining of lesional tissue from all patients showed the presence of treponemal organisms in dermal blood vessels. This new preliminary evidence adds some support to a circulating immune complex-mediated pathogenesis of cutaneous lesions in human secondary syphilis.

Original languageEnglish (US)
Pages (from-to)564-571
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume14
Issue number4
StatePublished - 1986
Externally publishedYes

Fingerprint

cutaneous Syphilis
Antigen-Antibody Complex
Blood Vessels
Skin
Intradermal Injections
Textbooks
Histamine
Fluorescent Antibody Technique
Secondary syphilis
Staining and Labeling
Serum

ASJC Scopus subject areas

  • Dermatology

Cite this

McNeely, M. C., Jorizzo, J. L., Solomon, A. J., Smith, E. B., Cavallo, T., & Sanchez, R. L. (1986). Cutaneous secondary syphilis: Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis. Journal of the American Academy of Dermatology, 14(4), 564-571.

Cutaneous secondary syphilis : Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis. / McNeely, M. C.; Jorizzo, J. L.; Solomon, Alvin Jr; Smith, E. B.; Cavallo, T.; Sanchez, R. L.

In: Journal of the American Academy of Dermatology, Vol. 14, No. 4, 1986, p. 564-571.

Research output: Contribution to journalArticle

McNeely, MC, Jorizzo, JL, Solomon, AJ, Smith, EB, Cavallo, T & Sanchez, RL 1986, 'Cutaneous secondary syphilis: Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis', Journal of the American Academy of Dermatology, vol. 14, no. 4, pp. 564-571.
McNeely, M. C. ; Jorizzo, J. L. ; Solomon, Alvin Jr ; Smith, E. B. ; Cavallo, T. ; Sanchez, R. L. / Cutaneous secondary syphilis : Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis. In: Journal of the American Academy of Dermatology. 1986 ; Vol. 14, No. 4. pp. 564-571.
@article{95245a0d333340dba0b1336e78bb58a0,
title = "Cutaneous secondary syphilis: Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis",
abstract = "A circulating immune complex-mediated pathogenesis for lesions of secondary syphilis has been postulated. Textbook descriptions of a lymphoplasmacytic histopathologic picture have contradicted a role for circulating immune complexes in lesion pathogenesis. Four patients with early cutaneous lesions of secondary syphilis were studied. All four patients had serum Raji cell and/or Clq binding assay evidence for circulating immune complexes. Three patients showed a neutrophilic vascular reaction on histologic study of early lesions. The patients studied had immunofluorescence microscopic evidence of immunoreactant deposition in dermal blood vessels (4 hours) and/or a neutrophilic vascular reaction (24 hours) after intradermal histamine injection. Dieterle staining of lesional tissue from all patients showed the presence of treponemal organisms in dermal blood vessels. This new preliminary evidence adds some support to a circulating immune complex-mediated pathogenesis of cutaneous lesions in human secondary syphilis.",
author = "McNeely, {M. C.} and Jorizzo, {J. L.} and Solomon, {Alvin Jr} and Smith, {E. B.} and T. Cavallo and Sanchez, {R. L.}",
year = "1986",
language = "English (US)",
volume = "14",
pages = "564--571",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Cutaneous secondary syphilis

T2 - Preliminary immunohistopathologic support for a role for immune complexes in lesion pathogenesis

AU - McNeely, M. C.

AU - Jorizzo, J. L.

AU - Solomon, Alvin Jr

AU - Smith, E. B.

AU - Cavallo, T.

AU - Sanchez, R. L.

PY - 1986

Y1 - 1986

N2 - A circulating immune complex-mediated pathogenesis for lesions of secondary syphilis has been postulated. Textbook descriptions of a lymphoplasmacytic histopathologic picture have contradicted a role for circulating immune complexes in lesion pathogenesis. Four patients with early cutaneous lesions of secondary syphilis were studied. All four patients had serum Raji cell and/or Clq binding assay evidence for circulating immune complexes. Three patients showed a neutrophilic vascular reaction on histologic study of early lesions. The patients studied had immunofluorescence microscopic evidence of immunoreactant deposition in dermal blood vessels (4 hours) and/or a neutrophilic vascular reaction (24 hours) after intradermal histamine injection. Dieterle staining of lesional tissue from all patients showed the presence of treponemal organisms in dermal blood vessels. This new preliminary evidence adds some support to a circulating immune complex-mediated pathogenesis of cutaneous lesions in human secondary syphilis.

AB - A circulating immune complex-mediated pathogenesis for lesions of secondary syphilis has been postulated. Textbook descriptions of a lymphoplasmacytic histopathologic picture have contradicted a role for circulating immune complexes in lesion pathogenesis. Four patients with early cutaneous lesions of secondary syphilis were studied. All four patients had serum Raji cell and/or Clq binding assay evidence for circulating immune complexes. Three patients showed a neutrophilic vascular reaction on histologic study of early lesions. The patients studied had immunofluorescence microscopic evidence of immunoreactant deposition in dermal blood vessels (4 hours) and/or a neutrophilic vascular reaction (24 hours) after intradermal histamine injection. Dieterle staining of lesional tissue from all patients showed the presence of treponemal organisms in dermal blood vessels. This new preliminary evidence adds some support to a circulating immune complex-mediated pathogenesis of cutaneous lesions in human secondary syphilis.

UR - http://www.scopus.com/inward/record.url?scp=0022656324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022656324&partnerID=8YFLogxK

M3 - Article

C2 - 3514703

AN - SCOPUS:0022656324

VL - 14

SP - 564

EP - 571

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 4

ER -