Cutaneous responses to vaccinia in individuals with previous smallpox vaccination

Eric L. Simpson, Michelle Hercher, Erika K. Hammarlund, Matthew W. Lewis, Mark K. Slifka, Jon M. Hanifin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.

Original languageEnglish (US)
Pages (from-to)442-444
Number of pages3
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Sep 2007

ASJC Scopus subject areas

  • Dermatology


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