Abstract
Cutaneous/systemic plasmacytosis (C/SP) is a plasma cell disorder characterized by reddish-brown patches, lymphadenopathy, and hypergammaglobulinemia. The degree to which C/SP overlaps with other plasma cell proliferative disorders and neoplasms is incompletely understood. We present the case of a patient with a several-year history of cutaneous plasmacytosis and evidence of systemic involvement with concurrent idiopathic multicentric Castleman disease (iMCD) involving a lymph node. There have been only a few reports of systemic iMCD preceded by a long, asymptomatic phase of cutaneous manifestations. We discuss the relationship between C/SP and iMCD and elaborate on the pathophysiological overlap of these 2 conditions and potential similarities in their pathogenesis. We suggest that the 2 diseases may represent the same entity presenting on a spectrum, with individuals diagnosed with C/SP at risk for progression to iMCD.
Original language | English (US) |
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Pages (from-to) | 294-296 |
Number of pages | 3 |
Journal | American Journal of Dermatopathology |
Volume | 44 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2022 |
Externally published | Yes |
Keywords
- cutaneous plasmacytosis, systemic plasmacytosis, idiopathic multicentric Castleman's disease, multicentric plasmacytic castleman's disease, multicentric Castleman's Disease, HHV-8
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Dermatology