Cutaneous melanomas in patients treated with psoralens plus ultraviolet A: A case report and the experience of the PUVA Follow-up Study

Aditya K. Gupta, Neil A. Swanson, Thomas F. Anderson

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Psoralens plus ultraviolet A (PUVA) therapy is widely used in the treatment of psoriasis and other cutaneous conditions. We present the case of a patient who developed a superficial spreading melanoma 3 years after first being treated with PUVA. The development of melanomas in patients receiving PUVA is reviewed. During 13,224 person-years of prospective follow-up of 1380 patients enrolled in the PUVA follow-up study, three melanomas were diagnosed, which does not differ significantly from the expected rate (relative risk = 1.5 with 90% confidence interval 0.3 to 7.3). However, considering the effects of PUVA on melanocytes and that the development of melanomas may have a long latent period, continued follow-up studies are indicated.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalJournal of the American Academy of Dermatology
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Dermatology

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