TY - JOUR
T1 - Cutaneous melanomas in patients treated with psoralens plus ultraviolet A
T2 - A case report and the experience of the PUVA Follow-up Study
AU - Gupta, Aditya K.
AU - Swanson, Neil A.
AU - Anderson, Thomas F.
N1 - Funding Information:
From the Department of Dermatology, University of Michigan, Ann Arbor,* and the Department of Dermatology( Beth Israel Hospital), Harvard Medical School, Boston,** and 15 other centers.*** Supported in part by the Babcock Foundation.
PY - 1988
Y1 - 1988
N2 - Psoralens plus ultraviolet A (PUVA) therapy is widely used in the treatment of psoriasis and other cutaneous conditions. We present the case of a patient who developed a superficial spreading melanoma 3 years after first being treated with PUVA. The development of melanomas in patients receiving PUVA is reviewed. During 13,224 person-years of prospective follow-up of 1380 patients enrolled in the PUVA follow-up study, three melanomas were diagnosed, which does not differ significantly from the expected rate (relative risk = 1.5 with 90% confidence interval 0.3 to 7.3). However, considering the effects of PUVA on melanocytes and that the development of melanomas may have a long latent period, continued follow-up studies are indicated.
AB - Psoralens plus ultraviolet A (PUVA) therapy is widely used in the treatment of psoriasis and other cutaneous conditions. We present the case of a patient who developed a superficial spreading melanoma 3 years after first being treated with PUVA. The development of melanomas in patients receiving PUVA is reviewed. During 13,224 person-years of prospective follow-up of 1380 patients enrolled in the PUVA follow-up study, three melanomas were diagnosed, which does not differ significantly from the expected rate (relative risk = 1.5 with 90% confidence interval 0.3 to 7.3). However, considering the effects of PUVA on melanocytes and that the development of melanomas may have a long latent period, continued follow-up studies are indicated.
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U2 - 10.1016/S0190-9622(88)70153-X
DO - 10.1016/S0190-9622(88)70153-X
M3 - Article
C2 - 3403747
AN - SCOPUS:0023680718
SN - 0190-9622
VL - 19
SP - 67
EP - 76
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -