Cutaneous melanomas in patients treated with psoralens plus ultraviolet A. A case report and the experience of the PUVA follow-up study

A. K. Gupta, Neil Swanson, N. A. Swanson, T. F. Anderson, J. Voorhes, T. B. Fitzpatrick, E. Gonzales, K. Arndt, E. Abel, B. Wintroub, J. H. Epstein, J. Wolf, T. P. Nigra, R. Armstrong, L. Harber, S. Muller, J. R. Taylor, P. Frost, S. N. Horwitz

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Abstract

Psoralens plus ultraviolet A (PUVA) therapy is widely used in the treatment of psoriasis and other cutaneous conditions. We present the case of a patient who developed a superficial spreading melanoma 3 years after first being treated with PUVA. The development of melanomas in patients receiving PUVA is reviewed. During 13,224 person-years of prospective follow-up of 1380 patients enrolled in the PUVA follow-up study, three melanomas were diagnosed, which does not differ significantly from the expected rate (relative risk = 1.5 with 90% confidence interval 0.3 to 7.3). However, considering the effects of PUVA on melanocytes and that the development of melanomas may have a long latent period, continued follow-up studies are indicated.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalJournal of the American Academy of Dermatology
Volume19
Issue number1 I
StatePublished - 1988
Externally publishedYes

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Melanoma
Skin
PUVA Therapy
Melanocytes
Psoriasis
Confidence Intervals
Furocoumarins
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Gupta, A. K., Swanson, N., Swanson, N. A., Anderson, T. F., Voorhes, J., Fitzpatrick, T. B., ... Horwitz, S. N. (1988). Cutaneous melanomas in patients treated with psoralens plus ultraviolet A. A case report and the experience of the PUVA follow-up study. Journal of the American Academy of Dermatology, 19(1 I), 67-76.

Cutaneous melanomas in patients treated with psoralens plus ultraviolet A. A case report and the experience of the PUVA follow-up study. / Gupta, A. K.; Swanson, Neil; Swanson, N. A.; Anderson, T. F.; Voorhes, J.; Fitzpatrick, T. B.; Gonzales, E.; Arndt, K.; Abel, E.; Wintroub, B.; Epstein, J. H.; Wolf, J.; Nigra, T. P.; Armstrong, R.; Harber, L.; Muller, S.; Taylor, J. R.; Frost, P.; Horwitz, S. N.

In: Journal of the American Academy of Dermatology, Vol. 19, No. 1 I, 1988, p. 67-76.

Research output: Contribution to journalArticle

Gupta, AK, Swanson, N, Swanson, NA, Anderson, TF, Voorhes, J, Fitzpatrick, TB, Gonzales, E, Arndt, K, Abel, E, Wintroub, B, Epstein, JH, Wolf, J, Nigra, TP, Armstrong, R, Harber, L, Muller, S, Taylor, JR, Frost, P & Horwitz, SN 1988, 'Cutaneous melanomas in patients treated with psoralens plus ultraviolet A. A case report and the experience of the PUVA follow-up study', Journal of the American Academy of Dermatology, vol. 19, no. 1 I, pp. 67-76.
Gupta, A. K. ; Swanson, Neil ; Swanson, N. A. ; Anderson, T. F. ; Voorhes, J. ; Fitzpatrick, T. B. ; Gonzales, E. ; Arndt, K. ; Abel, E. ; Wintroub, B. ; Epstein, J. H. ; Wolf, J. ; Nigra, T. P. ; Armstrong, R. ; Harber, L. ; Muller, S. ; Taylor, J. R. ; Frost, P. ; Horwitz, S. N. / Cutaneous melanomas in patients treated with psoralens plus ultraviolet A. A case report and the experience of the PUVA follow-up study. In: Journal of the American Academy of Dermatology. 1988 ; Vol. 19, No. 1 I. pp. 67-76.
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abstract = "Psoralens plus ultraviolet A (PUVA) therapy is widely used in the treatment of psoriasis and other cutaneous conditions. We present the case of a patient who developed a superficial spreading melanoma 3 years after first being treated with PUVA. The development of melanomas in patients receiving PUVA is reviewed. During 13,224 person-years of prospective follow-up of 1380 patients enrolled in the PUVA follow-up study, three melanomas were diagnosed, which does not differ significantly from the expected rate (relative risk = 1.5 with 90{\%} confidence interval 0.3 to 7.3). However, considering the effects of PUVA on melanocytes and that the development of melanomas may have a long latent period, continued follow-up studies are indicated.",
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AU - Swanson, Neil

AU - Swanson, N. A.

AU - Anderson, T. F.

AU - Voorhes, J.

AU - Fitzpatrick, T. B.

AU - Gonzales, E.

AU - Arndt, K.

AU - Abel, E.

AU - Wintroub, B.

AU - Epstein, J. H.

AU - Wolf, J.

AU - Nigra, T. P.

AU - Armstrong, R.

AU - Harber, L.

AU - Muller, S.

AU - Taylor, J. R.

AU - Frost, P.

AU - Horwitz, S. N.

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AB - Psoralens plus ultraviolet A (PUVA) therapy is widely used in the treatment of psoriasis and other cutaneous conditions. We present the case of a patient who developed a superficial spreading melanoma 3 years after first being treated with PUVA. The development of melanomas in patients receiving PUVA is reviewed. During 13,224 person-years of prospective follow-up of 1380 patients enrolled in the PUVA follow-up study, three melanomas were diagnosed, which does not differ significantly from the expected rate (relative risk = 1.5 with 90% confidence interval 0.3 to 7.3). However, considering the effects of PUVA on melanocytes and that the development of melanomas may have a long latent period, continued follow-up studies are indicated.

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