Current understanding of the corpus luteum in women and nonhuman primates

Despite the important advances detailed in this review, our understanding of the factors and mechanisms controlling the function of the corpus luteum in the menstrual cycle is rudimentary. Luteolysis remains a mystery. As the activities and interactions between different cell types in the corpus luteum are defined and the role(s) of endocrine, paracrine, and autocrine factors are elucidated, however, we should begin to understand the 'self-destruct' process at the end of the cycle. As cellular and molecular approaches combine with physiologic techniques, new information will be available to address the clinical issues of luteal dysfunction which perplex us all.