Current status of neuroprotective agents in the treatment of acute ischemic stroke.

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25 Citations (Scopus)

Abstract

To keep ischemic brain cells alive, neuroprotective agents target events in the ischemic cascade that might be injurious to the cells. They can be divided broadly into groups that restore ion balance, block receptors, prevent reperfusion injury, or promote neuronal healing. To date, neuroprotective agents have either shown a lack of efficacy in clinical stroke trials or been limited by side effects. Ongoing clinical trials with novel agents are trying to enroll a more homogeneous population of stroke patients in an effort to demonstrate treatment benefit.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalCurrent Neurology and Neuroscience Reports
Volume1
Issue number1
StatePublished - Jan 2001

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Neuroprotective Agents
Stroke
Clinical Trials
Reperfusion Injury
Ions
Brain
Therapeutics
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

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title = "Current status of neuroprotective agents in the treatment of acute ischemic stroke.",
abstract = "To keep ischemic brain cells alive, neuroprotective agents target events in the ischemic cascade that might be injurious to the cells. They can be divided broadly into groups that restore ion balance, block receptors, prevent reperfusion injury, or promote neuronal healing. To date, neuroprotective agents have either shown a lack of efficacy in clinical stroke trials or been limited by side effects. Ongoing clinical trials with novel agents are trying to enroll a more homogeneous population of stroke patients in an effort to demonstrate treatment benefit.",
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