Current issues in the management of advanced squamous cell carcinoma of the penis

Samira Syed, Tony Y. Eng, Charles Thomas, Ian M. Thompson, Geoffrey R. Weiss

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Effective treatment of penile carcinoma incorporates three modalities: surgery, radiation and chemotherapy. Surgery alone may offer a high cure rate in early stages of the disease. In certain patients radiation therapy may be utilized to eradicate the tumor and allow organ preservation. For patients with locally advanced disease, multi-modality approaches incorporating adjuvant or neoadjuvant chemotherapy and radiation therapy need to be studied. This approach may confer a survival benefit to a group that would otherwise have a poor prognosis. Finally, in the setting of metastatic disease, less toxic and more effective combination chemotherapy are sought. Novel targeted therapies that have been successful in squamous cell carcinoma at other sites must also be studied in this disease. We believe that multi-institutional trials should be designed in order to obtain prospective benchmark data from which to make valid comparisons of outcome.

Original languageEnglish (US)
Pages (from-to)431-438
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume21
Issue number6
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Penis
Squamous Cell Carcinoma
Radiotherapy
Organ Preservation
Benchmarking
Drug Therapy
Neoadjuvant Therapy
Poisons
Combination Drug Therapy
Radiation
Carcinoma
Survival
Therapeutics
Neoplasms

Keywords

  • Chemotherapy
  • Novel agents
  • Penile cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Current issues in the management of advanced squamous cell carcinoma of the penis. / Syed, Samira; Eng, Tony Y.; Thomas, Charles; Thompson, Ian M.; Weiss, Geoffrey R.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 21, No. 6, 11.2003, p. 431-438.

Research output: Contribution to journalArticle

Syed, Samira ; Eng, Tony Y. ; Thomas, Charles ; Thompson, Ian M. ; Weiss, Geoffrey R. / Current issues in the management of advanced squamous cell carcinoma of the penis. In: Urologic Oncology: Seminars and Original Investigations. 2003 ; Vol. 21, No. 6. pp. 431-438.
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