Current Concepts in Brain Resuscitation

Jeffrey R. Kirsch, J. Michael Dean, Mark C. Rogers

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

• In spite of the tremendous amount of effort and money put forth to reduce morbidity and mortality associated with global cerebral ischemia, the outlook for patients suffering an ischemic insult remains dismal. The lack of a sufficient substrate supply during the period of ischemia as well as the production of toxic metabolites in response to ischemia have been incriminated as key factors causing brain damage. As discussed in this article, modes of therapy have included efforts to minimize the duration of ischemia (eg, effective cardiopulmonary resuscitation, hemodilution, heparinization, calcium antagonists) and decrease the production of toxic metabolites (eg, barbiturates, calcium antagonists). Although the barbiturates have also been proposed to decrease the metabolic needs during ischemia, they have no therapeutic value for global cerebral ischemia. The initial evaluation of the calcium antagonists has been more promising.

Original languageEnglish (US)
Pages (from-to)1413-1419
Number of pages7
JournalArchives of internal medicine
Volume146
Issue number7
DOIs
StatePublished - Jul 1986

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ASJC Scopus subject areas

  • Internal Medicine

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