Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall

Jens Berli, Justin M. Broyles, Denver Lough, Sachin M. Shridharani, Danielle Rochlin, Damon S. Cooney, W. P Andrew Lee, Gerald Brandacher, Justin M. Sacks

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Introduction: Abdominal wall vascularized composite allotransplantation (AW-VCA) is a rarely utilized technique for large composite abdominal wall defects. The goal of this article is to systematically review the literature and current concepts of AW-VCA, outline the challenges ahead, and provide an outlook for the future. Methods: Systematic review of the literature was performed using MEDLINE, EMBASE, and PubMed to identify relevant articles discussing results of AW-VCA. Cadaver and animal studies were excluded from the systematic review, but selectively included in the discussion. Results: The resultant five papers report their results on AW-VCA(Transplantation, 85, 2008, 1607; Am J Transplant, 7, 2007, 1304; Transplant Proc, 41, 2009, 521; Transplant Proc, 36, 2004, 1561; Lancet, 361, 2003, 2173). These papers represent the result of two study groups in which a total of 18 AW-VCA were performed in 17 patients. Two different operative approaches were used. Overall flap/graft survival was 88%. No mortality related to the transplant was reported. One cadaver study and two animal models were identified and separately presented (Transplant Proc, 43, 2011, 1701; Transplantation, 90, 2010, 1590; Journal of Surgical Research, 162, 2010, 314). Conclusion: Literature review reports AW-VCA is technically feasible with low morbidity and mortality. Functional outcomes are not reported and minimally considered. With advancements in vascularized composite allotransplantation research and decreasing toxicity of immunosuppression therapies and immunomodulatory regimens, AW-VCA can be applied in circumstances beyond conjunction with visceral transplantation.

Original languageEnglish (US)
Pages (from-to)781-789
Number of pages9
JournalClinical Transplantation
Volume27
Issue number6
DOIs
StatePublished - Nov 2013
Externally publishedYes

Fingerprint

Vascularized Composite Allotransplantation
Abdominal Wall
Transplants
Transplantation
Cadaver
Immunomodulation
Mortality
Graft Survival
Research
PubMed
MEDLINE
Immunosuppression
Animal Models
Morbidity

Keywords

  • Abdominal wall reconstruction
  • Abdominal wall transplant
  • Antigenicity
  • Immunosuppression
  • Systematic review
  • Tolerance
  • Vascularized composite allotransplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Berli, J., Broyles, J. M., Lough, D., Shridharani, S. M., Rochlin, D., Cooney, D. S., ... Sacks, J. M. (2013). Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall. Clinical Transplantation, 27(6), 781-789. https://doi.org/10.1111/ctr.12243

Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall. / Berli, Jens; Broyles, Justin M.; Lough, Denver; Shridharani, Sachin M.; Rochlin, Danielle; Cooney, Damon S.; Lee, W. P Andrew; Brandacher, Gerald; Sacks, Justin M.

In: Clinical Transplantation, Vol. 27, No. 6, 11.2013, p. 781-789.

Research output: Contribution to journalReview article

Berli, J, Broyles, JM, Lough, D, Shridharani, SM, Rochlin, D, Cooney, DS, Lee, WPA, Brandacher, G & Sacks, JM 2013, 'Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall', Clinical Transplantation, vol. 27, no. 6, pp. 781-789. https://doi.org/10.1111/ctr.12243
Berli, Jens ; Broyles, Justin M. ; Lough, Denver ; Shridharani, Sachin M. ; Rochlin, Danielle ; Cooney, Damon S. ; Lee, W. P Andrew ; Brandacher, Gerald ; Sacks, Justin M. / Current concepts and systematic review of vascularized composite allotransplantation of the abdominal wall. In: Clinical Transplantation. 2013 ; Vol. 27, No. 6. pp. 781-789.
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abstract = "Introduction: Abdominal wall vascularized composite allotransplantation (AW-VCA) is a rarely utilized technique for large composite abdominal wall defects. The goal of this article is to systematically review the literature and current concepts of AW-VCA, outline the challenges ahead, and provide an outlook for the future. Methods: Systematic review of the literature was performed using MEDLINE, EMBASE, and PubMed to identify relevant articles discussing results of AW-VCA. Cadaver and animal studies were excluded from the systematic review, but selectively included in the discussion. Results: The resultant five papers report their results on AW-VCA(Transplantation, 85, 2008, 1607; Am J Transplant, 7, 2007, 1304; Transplant Proc, 41, 2009, 521; Transplant Proc, 36, 2004, 1561; Lancet, 361, 2003, 2173). These papers represent the result of two study groups in which a total of 18 AW-VCA were performed in 17 patients. Two different operative approaches were used. Overall flap/graft survival was 88{\%}. No mortality related to the transplant was reported. One cadaver study and two animal models were identified and separately presented (Transplant Proc, 43, 2011, 1701; Transplantation, 90, 2010, 1590; Journal of Surgical Research, 162, 2010, 314). Conclusion: Literature review reports AW-VCA is technically feasible with low morbidity and mortality. Functional outcomes are not reported and minimally considered. With advancements in vascularized composite allotransplantation research and decreasing toxicity of immunosuppression therapies and immunomodulatory regimens, AW-VCA can be applied in circumstances beyond conjunction with visceral transplantation.",
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