Current and potential imaging applications of ferumoxytol for magnetic resonance imaging

Gerda B. Toth, Csanad G. Varallyay, Andrea Horvath, Mustafa R. Bashir, Peter L. Choyke, Heike E. Daldrup-Link, Edit Dosa, John Paul Finn, Seymur Gahramanov, Mukesh Harisinghani, Iain Macdougall, Alexander Neuwelt, Shreyas S. Vasanawala, Prakash Ambady, Ramon Barajas, Justin S. Cetas, Jeremy Ciporen, Thomas J. DeLoughery, Nancy D. Doolittle, Rongwei FuJohn Grinstead, Alexander R. Guimaraes, Bronwyn E. Hamilton, Xin Li, Heather L. McConnell, Leslie L. Muldoon, Gary Nesbit, Joao P. Netto, David Petterson, William D. Rooney, Daniel Schwartz, Laszlo Szidonya, Edward A. Neuwelt

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool. Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in patients with impaired renal function. Other attractive imaging features of i.v. ferumoxytol include a prolonged blood pool phase and delayed intracellular uptake. With its unique pharmacologic, metabolic, and imaging properties, ferumoxytol may play a crucial role in future magnetic resonance imaging of the central nervous system, various organs outside the central nervous system, and the cardiovascular system. Preclinical and clinical studies have demonstrated the overall safety and effectiveness of this novel contrast agent, with rarely occurring anaphylactoid reactions. The purpose of this review is to describe the general and organ-specific properties of ferumoxytol, as well as the advantages and potential pitfalls associated with its use in magnetic resonance imaging. To more fully demonstrate the applications of ferumoxytol throughout the body, an imaging atlas was created and is available online as supplementary material.

Original languageEnglish (US)
Pages (from-to)47-66
Number of pages20
JournalKidney International
Volume92
Issue number1
DOIs
StatePublished - Jul 2017

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Keywords

  • chronic kidney disease
  • magnetic resonance imaging
  • nephrotoxicity

ASJC Scopus subject areas

  • Nephrology

Cite this

Toth, G. B., Varallyay, C. G., Horvath, A., Bashir, M. R., Choyke, P. L., Daldrup-Link, H. E., Dosa, E., Finn, J. P., Gahramanov, S., Harisinghani, M., Macdougall, I., Neuwelt, A., Vasanawala, S. S., Ambady, P., Barajas, R., Cetas, J. S., Ciporen, J., DeLoughery, T. J., Doolittle, N. D., ... Neuwelt, E. A. (2017). Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney International, 92(1), 47-66. https://doi.org/10.1016/j.kint.2016.12.037