Cultured human skin

Heterotransplantation

Molly Kulesz-Martin, Arthur Birnkrant, William F. Mclimans

Research output: Contribution to journalArticle

Abstract

We have reported that human skin, cultured in a controlled environment system (steady state), yields epidermis-like growth from adult donor split thickness specimens. A procedure for transplantation of such cellular outgrowths to athymic nude mice for functional and morphologic evaluations is reported. Successful transplants were definitively scored by the presence of histologic epidermal markers and human glucose phosphate isomerase. We suggest that the transplantation procedures reported here may contribute to the knowledge required for the use of autologous cultured skin in patients with large skin wounds.

Original languageEnglish (US)
Pages (from-to)207-215
Number of pages9
JournalPathobiology
Volume50
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Nude Mice
Skin
Transplantation
Controlled Environment
Epidermis
Tissue Donors
Transplants
Wounds and Injuries
Growth
human GPI protein

Keywords

  • Human skin culture
  • Nude mice
  • Transplantation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Cultured human skin : Heterotransplantation. / Kulesz-Martin, Molly; Birnkrant, Arthur; Mclimans, William F.

In: Pathobiology, Vol. 50, No. 4, 1982, p. 207-215.

Research output: Contribution to journalArticle

Kulesz-Martin, M, Birnkrant, A & Mclimans, WF 1982, 'Cultured human skin: Heterotransplantation', Pathobiology, vol. 50, no. 4, pp. 207-215. https://doi.org/10.1159/000163148
Kulesz-Martin, Molly ; Birnkrant, Arthur ; Mclimans, William F. / Cultured human skin : Heterotransplantation. In: Pathobiology. 1982 ; Vol. 50, No. 4. pp. 207-215.
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