Cultured human retinal pigment epithelial cells express basic fibroblast growth factor and its receptor

Mark D. Stcrnfeld, Joseph E. Robertson, Gary D. Shipley, Jeanne Tsai, James T. Rosenbaum

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Basic fibroblast growth factor (bFGF) has been implicated in the maintenance of neuronal differentiation, the induction of neovascularization and intravitreal proliferative diseases. We have found that human retinal pigment epithelial (RFE) cells grown in vitro transcribe the bFGF gene and synthesize a peptide that crossreacts with anti-bFGF antibodies. In culture, these cells appear to release activity with biological and biochemical properties similar to bFGF. RPE cells have specific bFGF receptors and proliferate in response to bFGF, Thus, it is possible that the RPE cell is an important source of retinal bFGF and may respond to bFGF in an autocrine manner.

Original languageEnglish (US)
Pages (from-to)1029-1037
Number of pages9
JournalCurrent Eye Research
Volume8
Issue number10
DOIs
StatePublished - Jan 1 1989

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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