Culture-proven endophthalmitis after intravitreal injection

A 10-year analysis

Joseph M. Simonett, Austin Igelman, Stanford C. Taylor, John Campbell, Thomas Hwang, Phoebe Lin, Andreas (Andy) Lauer, Christina Flaxel

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVE: To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-Associated, culture-proven endophthalmitis. PATIENTS AND METHODS: All patients seen at a tertiary referral center with culture-proven endophthalmitis associated with an IVI between June 2007 and July 2017 were included in this retrospective analysis. RESULTS: Thirty-five patients with culture-positive endophthalmitis following IVI were identified. All gram-positive organisms (34 of 35) were susceptible to vancomycin. Cases due to pathogens associated with oral or respiratory flora were common (31.4%, n = 11), presented earlier (2.0 days vs. 4.6 days, P < .001), were more likely to undergo pars plana vitrectomy (81.8% vs. 25.0%, P = .002) and had worse visual acuity outcomes. CONCLUSION: IVI-Associated endophthalmitis pathogens and anti-microbial susceptibilities in the Pacific Northwest are similar to those reported from other geographic locations. Bacteria associated with the oral and respiratory flora are common isolates that result in a more aggressive course and worse visual outcomes.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2019

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Intravitreal Injections
Endophthalmitis
antineoplaston A10
Northwestern United States
Geographic Locations
Temazepam
Vitrectomy
Vancomycin
Microbiology
Tertiary Care Centers
Visual Acuity
Bacteria

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Culture-proven endophthalmitis after intravitreal injection : A 10-year analysis. / Simonett, Joseph M.; Igelman, Austin; Taylor, Stanford C.; Campbell, John; Hwang, Thomas; Lin, Phoebe; Lauer, Andreas (Andy); Flaxel, Christina.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 50, No. 1, 01.01.2019, p. 33-38.

Research output: Contribution to journalArticle

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