CT of cerebral abnormalities in precocious puberty

K. G. Rieth, F. Comite, A. J. Dwyer, M. J. Nelson, O. Pescovitz, T. H. Shawker, G. B. Cutler, D. L. Loriaux

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


True precocious puberty occurs as a result of the premature release of luteinizing hormone-releasing hormone from the hypothalamus, which stimulated the secretion of the pituitary gonadotrophins, which in turn stimulate the gonadal sex steroids. The differential diagnosis of true precocious puberty includes cerebral and idiopathic categories. This differentiation, which cannot be made endocrinologically due to similarities in pituitary gonadotropin and sex steroid levels, may be facilitated by high-resolution CT. A CT study of 90 children (73 girls and 17 boys) with true precocious puberty was performed at the NIH to detect cerebral causes of their precocious puberty. Thirty-four cerebral abnormalities were demonstrated in 32 children, 16 boys and 16 girls. These included hypothalamic hamartomas (17), hypothalamic astrocytoma (one), optic chiasm lesions (six), ventricular abnormalities (eight), arachnoid cyst (one), and teratoma (one). The CT appearance of these cerebral abnormalities is discussed and related to the endocrinologic findings and natural history of true precocious puberty. A practical neuroradiologic approach to the evaluation of children with precocious puberty is presented.

Original languageEnglish (US)
Pages (from-to)1231-1238
Number of pages8
JournalAmerican Journal of Roentgenology
Issue number6
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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