CT metrics of airway disease and emphysema in severe COPD

Woo Jin Kim, Edwin K. Silverman, Eric Hoffman, Gerard J. Criner, Zab Mosenifar, Frank C. Sciurba, Barry J. Make, Vincent Carey, Raúl San José Estépar, Alejandro Diaz, John J. Reilly, Fernando J. Martinez, George R. Washko, Alfred P. Fishman, Betsy Ann Bozzarello, Ameena Al-Amin, Marcia Katz, Carolyn Wheeler, Elaine Baker, Peter BarnardPhil Cagle, James Carter, Sophia Chatziioannou, Karla Conejo-Gonzales, Kimberly Dubose, John Haddad, David Hicks, Neal Kleiman, Mary Milburn-Barnes, Chinh Nguyen, Michael Reardon, Joseph Reeves-Viets, Steven Sax, Amir Sharafkhaneh, Owen Wilson, Christine Young, Rafael Espada, Rose Butanda, Minnie Ellisor, Pamela Fox, Katherine Hale, Everett Hood, Amy Jahn, Satish Jhingran, Karen King, Charles Miller, Imran Nizami, Todd Officer, Jeannie Ricketts, Joe Rodarte, Robert Teague, Kedren Williams, John Reilly, David Sugarbaker, Carol Fanning, Simon Body, Sabine Duffy, Vladmir Formanek, Anne Fuhlbrigge, Philip Hartigan, Sarah Hooper, Andetta Hunsaker, Francine Jacobson, Marilyn Moy, Susan Peterson, Roger Russell, Diane Saunders, Scott Swanson, Rob McKenna, Zab Mohsenifar, Carol Geaga, Manmohan Biring, Susan Clark, Jennifer Cutler, Robert Frantz, Peter Julien, Michael Lewis, Jennifer Minkoff-Rau, Valentina Yegyan, Milton Joyner, Malcolm De-Camp, James Stoller, Yvonne Meli, John Apostolakis, Darryl Atwell, Jeffrey Chapman, Pierre DeVilliers, Raed Dweik, Erik Kraenzler, Rosemary Lann, Nancy Kurokawa, Scott Marlow, Kevin McCarthy, Priscilla McCreight, Atul Mehta, Moulay Meziane, Omar Minai, Mindi Steiger, Kenneth White, Janet Maurer, Terri Durr, Charles Hearn, Susan Lubell, Peter O'Donovan, Robert Schilz, Mark Ginsburg, Byron Thomashow, Patricia Jellen, John Austin, Matthew Bartels, Yahya Berkmen, Patricia Berkoski, Frances Brogan, Amy Chong, Glenda DeMercado, Angela DiMango, Sandy Do, Bessie Kachulis, Arfa Khan, Berend Mets, Mitchell O'Shea, Gregory Pearson, Leonard Rossoff, Steven Scharf, Maria Shiau, Paul Simonelli, Kim Stavrolakes, Donna Tsang, Denise Vilotijevic, Chun Yip, Mike Mantinaos, Kerri McKeon, Jacqueline Pfeffer, Neil MacIntyre, R. Duane Davis, John Howe, R. Edward Coleman, Rebecca Crouch, Dora Greene, Katherine Grichnik, David Harpole, Abby Krichman, Brian Lawlor, Holman McAdams, John Plankeel, Susan Rinaldo-Gallo, Sheila Shearer, Jeanne Smith, Mark Stafford-Smith, Victor Tapson, Mark Steele, Jennifer Norten, James Utz, Claude Deschamps, Kathy Mieras, Martin Abel, Mark Allen, Deb Andrist, Gregory Aughenbaugh, Sharon Bendel, Eric Edell, Marlene Edgar, Bonnie Edwards, Beth Elliot, James Garrett, Delmar Gillespie, Judd Gurney, Boleyn Hammel, Karen Hanson, Lori Hanson, Gordon Harms, June Hart, Thomas Hartman, Robert Hyatt, Eric Jensen, Nicole Jenson, Sanjay Kalra, Philip Karsell, Jennifer Lamb, David Midthun, Carl Mottram, Stephen Swensen, Anne Marie Sykes, Karen Taylor, Norman Torres, Rolf Hubmayr, Daniel Miller, Sara Bartling, Kris Bradt, Barry Make, Marvin Pomerantz, Mary Gilmartin, Joyce Canterbury, Martin Carlos, Phyllis Dibbern, Enrique Fernandez, Lisa Geyman, Connie Hudson, David Lynch, John Newell, Robert Quaife, Jennifer Propst, Cynthia Raymond, Jane Whalen-Price, Kathy Winner, Martin Zamora, Reuben Cherniack, Philip Diaz, Patrick Ross, Tina Bees, Jan Drake, Charles Emery, Mark Gerhardt, Mark King, David Rittinger, Mahasti Rittinger, Keith Naunheim, Robert Gerber, Joan Osterloh, Susan Borosh, Willard Chamberlain, Sally Frese, Alan Hibbit, Mary Ellen Kleinhenz, Gregg Ruppel, Cary Stolar, Janice Willey, Francisco Alvarez, Cesar Keller, Gerard Criner, Satoshi Furukawa, Anne Marie Kuzma, Roger Barnette, Neil Brister, Kevin Carney, Wissam Chatila, Francis Cordova, Gilbert D'Alonzo, Michael Keresztury, Karen Kirsch, Chul Kwak, Kathy Lautensack, Madelina Lorenzon, Ubaldo Martin, Peter Rising, Scott Schartel, John Travaline, Gwendolyn Vance, Phillip Boiselle, Gerald O'Brien, Andrew Ries, Robert Kaplan, Catherine Ramirez, David Frankville, Paul Friedman, James Harrell, Jeffery Johnson, David Kapelanski, David Kupferberg, Catherine Larsen, Trina Limberg, Michael Magliocca, Frank J. Papatheofanis, Dawn Sassi-Dambron, Melissa Weeks, Mark Krasna, Henry Fessler, Iris Moskowitz, Timothy Gilbert, Jonathan Orens, David Shade, Stanley Siegelman, Kenneth Silver, Clarence Weir, Charles White, Fernando Martinez, Mark Iannettoni, Catherine Meldrum, William Bria, Kelly Campbell, Paul Christensen, Kevin Flaherty, Steven Gay, Paramjit Gill, Paul Kazanjian, Ella Kazerooni, Vivian Knieper, Tammy Ojo, Lewis Poole, Leslie Quint, Paul Rysso, Thomas Sisson, Mercedes True, Brian Woodcock, Lori Zaremba, Larry Kaiser, John Hansen-Flaschen, Mary Louise Dempsey, Abass Alavi, Theresa Alcorn, Selim Arcasoy, Judith Aronchick, Stanley Aukberg, Bryan Benedict, Susan Craemer, Ron Daniele, Jeffrey Edelman, Warren Gefter, Laura Kotler-Klein, Robert Kotloff, David Lipson, Wallace Miller, Richard O'Connell, Staci Opelman, Harold Palevsky, William Russell, Heather Sheaffer, Rodney Simcox, Susanne Snedeker, Jennifer Stone-Wynne, Gregory Tino, Peter Wahl, James Walter, Patricia Ward, David Zisman, James Mendez, Angela Wurster, Frank Sciurba, James Luketich, Colleen Witt, Gerald Ayres, Michael Donahoe, Carl Fuhrman, Robert Hoffman, Joan Lacomis, Joan Sexton, William Slivka, Diane Strollo, Erin Sullivan, Tomeka Simon, Catherine Wrona, Gerene Bauldoff, Manuel Brown, Elisabeth George, Robert Keenan, Theodore Kopp, Laurie Silfies, Joshua Benditt, Douglas Wood, Margaret Snyder, Kymberley Anable, Nancy Battaglia, Louie Boitano, Andrew Bowdle, Leighton Chan, Cindy Chwalik, Bruce Culver, Thurman Gillespy, David Godwin, Jeanne Hoffman, Andra Ibrahim, Diane Lockhart, Stephen Marglin, Kenneth Martay, Patricia McDowell, Donald Oxorn, Liz Roessler, Michelle Toshima, Susan Golden, Lynn Bosco, Yen Pin Chiang, Carolyn Clancy, Harry Handelsman, Steven M. Berkowitz, Tanisha Carino, Joe Chin, Jo Anna Baldwin, Karen McVearry, Anthony Norris, Sarah Shirey, Claudette Sikora, Steven Sheingold, Steven Piantadosi, James Tonascia, Patricia Belt, Amanda Blackford, Karen Collins, Betty Collison, Ryan Colvin, John Dodge, Michele Donithan, Vera Edmonds, Gregory L. Foster, Julie Fuller, Judith Harle, Rosetta Jackson, Shing Lee, Charlene Levine, Hope Livingston, Jill Meinert, Jennifer Meyers, Deborah Nowakowski, Kapreena Owens, Shangqian Qi, Michael Smith, Brett Simon, Paul Smith, Alice Sternberg, Mark Van Natta, Laura Wilson, Robert Wise, Robert M. Kaplan, J. Sanford Schwartz, Marianne C. Fahs, A. Mark Fendrick, Alan J. Moskowitz, Dev Pathak, Scott Ramsey, A. Laurie Shroyer, Judith Wagner, Roger Yusen, Ruth Etzioni, Sean Sullivan, Thomas Schroeder, Karma Kreizenbeck, Kristin Berry, Nadia Howlader, Janice Cook-Granroth, Angela Delsing, Junfeng Guo, Geoffrey McLennan, Brian Mullan, Chris Piker, Joseph Reinhardt, Blake Wood, Jered Sieren, William Stanford, John A. Waldhausen, Gordon Bernard, David DeMets, Mark Ferguson, Eddie Hoover, Robert Levine, Donald Mahler, A. John McSweeny, Jeanine Wiener-Kronish, Dale Williams, Magdy Younes, Charles Soltoff, Gail Weinmann, Joanne Deshler, Dean Follmann, James Kiley, Margaret Wu

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Background: CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear. Methods: Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV 1 and percent predicted value of FEV1 with CT scan measures of emphysema and airway disease. Results: In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV1% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (β = -5.2, p = 0.009; β = -2.6, p = 0.008, respectively) and %LAA-950 (β = -10.6, p = 0.03) with the postbronchodilator FEV1% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA). Conclusions: Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalCHEST
Volume136
Issue number2
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Kim, W. J., Silverman, E. K., Hoffman, E., Criner, G. J., Mosenifar, Z., Sciurba, F. C., Make, B. J., Carey, V., San José Estépar, R., Diaz, A., Reilly, J. J., Martinez, F. J., Washko, G. R., Fishman, A. P., Bozzarello, B. A., Al-Amin, A., Katz, M., Wheeler, C., Baker, E., ... Wu, M. (2009). CT metrics of airway disease and emphysema in severe COPD. CHEST, 136(2), 396-404. https://doi.org/10.1378/chest.08-2858