CT cholangiography in potential liver donors: Effect of premedication with intravenous morphine on biliary caliber and visualization

Richard S. Breiman, Fergus Coakley, Emily M. Webb, James J. Ellingson, John P. Roberts, Jennifer Kohr, Juergen Lutz, Naomi Knoess, Benjamin M. Yeh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To retrospectively determine whether premedication with intravenously administered morphine improves bile duct caliber and visualization in potential liver donors undergoing computed tomographic (CT) cholangiography. Materials and Methods: This was a retrospective single institution study approved by the institutional review board and compliant with requirements of the HIPAA. Multidetector CT cholangiography was performed after slow infusion of 20 mL of iodipamide meglumine 52% diluted in 80 mL of normal saline in 143 consecutive potential liver donors (81 men and 62 women; mean age, 37 years); 43 received premedication with intravenous morphine sulfate (0.04 mg per kilogram of body weight) and 100 did not. Two independent readers recorded common bile duct diameter and area on axial CT images. Readers also scored bile duct visualization, including all second-order biliary branches, on a four-point scale (0, not seen; 3, excellent visualization). Results: For scans obtained without and those obtained with morphine, there was no significant difference in the mean common bile duct diameter (4.1 vs 4.3 mm for reader 1 and 4.4 vs 4.6 mm for reader 2, respectively; P > .39 for both readers), in common bile duct area (20.7 vs 21.5 mm2, for reader 1 and 21.3 vs 20.2 mm2 for reader 2, respectively, P > .60 for both), or in second-order bile duct visualization score (2.34 vs 2.36 for reader 1 and 2.58 vs 2.50 for reader 2, respectively; P > .5 for both). Conclusion: The results suggest that premedication with intravenous morphine prior to CT cholangiography in potential liver donors does not increase bile duct caliber or improve biliary visualization.

Original languageEnglish (US)
Pages (from-to)733-737
Number of pages5
JournalRadiology
Volume247
Issue number3
DOIs
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Cholangiography
Premedication
Bile Ducts
Morphine
Common Bile Duct
Tissue Donors
Liver
Health Insurance Portability and Accountability Act
Research Ethics Committees
Body Weight

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

CT cholangiography in potential liver donors : Effect of premedication with intravenous morphine on biliary caliber and visualization. / Breiman, Richard S.; Coakley, Fergus; Webb, Emily M.; Ellingson, James J.; Roberts, John P.; Kohr, Jennifer; Lutz, Juergen; Knoess, Naomi; Yeh, Benjamin M.

In: Radiology, Vol. 247, No. 3, 06.2008, p. 733-737.

Research output: Contribution to journalArticle

Breiman, RS, Coakley, F, Webb, EM, Ellingson, JJ, Roberts, JP, Kohr, J, Lutz, J, Knoess, N & Yeh, BM 2008, 'CT cholangiography in potential liver donors: Effect of premedication with intravenous morphine on biliary caliber and visualization', Radiology, vol. 247, no. 3, pp. 733-737. https://doi.org/10.1148/radiol.2473070964
Breiman, Richard S. ; Coakley, Fergus ; Webb, Emily M. ; Ellingson, James J. ; Roberts, John P. ; Kohr, Jennifer ; Lutz, Juergen ; Knoess, Naomi ; Yeh, Benjamin M. / CT cholangiography in potential liver donors : Effect of premedication with intravenous morphine on biliary caliber and visualization. In: Radiology. 2008 ; Vol. 247, No. 3. pp. 733-737.
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abstract = "Purpose: To retrospectively determine whether premedication with intravenously administered morphine improves bile duct caliber and visualization in potential liver donors undergoing computed tomographic (CT) cholangiography. Materials and Methods: This was a retrospective single institution study approved by the institutional review board and compliant with requirements of the HIPAA. Multidetector CT cholangiography was performed after slow infusion of 20 mL of iodipamide meglumine 52{\%} diluted in 80 mL of normal saline in 143 consecutive potential liver donors (81 men and 62 women; mean age, 37 years); 43 received premedication with intravenous morphine sulfate (0.04 mg per kilogram of body weight) and 100 did not. Two independent readers recorded common bile duct diameter and area on axial CT images. Readers also scored bile duct visualization, including all second-order biliary branches, on a four-point scale (0, not seen; 3, excellent visualization). Results: For scans obtained without and those obtained with morphine, there was no significant difference in the mean common bile duct diameter (4.1 vs 4.3 mm for reader 1 and 4.4 vs 4.6 mm for reader 2, respectively; P > .39 for both readers), in common bile duct area (20.7 vs 21.5 mm2, for reader 1 and 21.3 vs 20.2 mm2 for reader 2, respectively, P > .60 for both), or in second-order bile duct visualization score (2.34 vs 2.36 for reader 1 and 2.58 vs 2.50 for reader 2, respectively; P > .5 for both). Conclusion: The results suggest that premedication with intravenous morphine prior to CT cholangiography in potential liver donors does not increase bile duct caliber or improve biliary visualization.",
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T1 - CT cholangiography in potential liver donors

T2 - Effect of premedication with intravenous morphine on biliary caliber and visualization

AU - Breiman, Richard S.

AU - Coakley, Fergus

AU - Webb, Emily M.

AU - Ellingson, James J.

AU - Roberts, John P.

AU - Kohr, Jennifer

AU - Lutz, Juergen

AU - Knoess, Naomi

AU - Yeh, Benjamin M.

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N2 - Purpose: To retrospectively determine whether premedication with intravenously administered morphine improves bile duct caliber and visualization in potential liver donors undergoing computed tomographic (CT) cholangiography. Materials and Methods: This was a retrospective single institution study approved by the institutional review board and compliant with requirements of the HIPAA. Multidetector CT cholangiography was performed after slow infusion of 20 mL of iodipamide meglumine 52% diluted in 80 mL of normal saline in 143 consecutive potential liver donors (81 men and 62 women; mean age, 37 years); 43 received premedication with intravenous morphine sulfate (0.04 mg per kilogram of body weight) and 100 did not. Two independent readers recorded common bile duct diameter and area on axial CT images. Readers also scored bile duct visualization, including all second-order biliary branches, on a four-point scale (0, not seen; 3, excellent visualization). Results: For scans obtained without and those obtained with morphine, there was no significant difference in the mean common bile duct diameter (4.1 vs 4.3 mm for reader 1 and 4.4 vs 4.6 mm for reader 2, respectively; P > .39 for both readers), in common bile duct area (20.7 vs 21.5 mm2, for reader 1 and 21.3 vs 20.2 mm2 for reader 2, respectively, P > .60 for both), or in second-order bile duct visualization score (2.34 vs 2.36 for reader 1 and 2.58 vs 2.50 for reader 2, respectively; P > .5 for both). Conclusion: The results suggest that premedication with intravenous morphine prior to CT cholangiography in potential liver donors does not increase bile duct caliber or improve biliary visualization.

AB - Purpose: To retrospectively determine whether premedication with intravenously administered morphine improves bile duct caliber and visualization in potential liver donors undergoing computed tomographic (CT) cholangiography. Materials and Methods: This was a retrospective single institution study approved by the institutional review board and compliant with requirements of the HIPAA. Multidetector CT cholangiography was performed after slow infusion of 20 mL of iodipamide meglumine 52% diluted in 80 mL of normal saline in 143 consecutive potential liver donors (81 men and 62 women; mean age, 37 years); 43 received premedication with intravenous morphine sulfate (0.04 mg per kilogram of body weight) and 100 did not. Two independent readers recorded common bile duct diameter and area on axial CT images. Readers also scored bile duct visualization, including all second-order biliary branches, on a four-point scale (0, not seen; 3, excellent visualization). Results: For scans obtained without and those obtained with morphine, there was no significant difference in the mean common bile duct diameter (4.1 vs 4.3 mm for reader 1 and 4.4 vs 4.6 mm for reader 2, respectively; P > .39 for both readers), in common bile duct area (20.7 vs 21.5 mm2, for reader 1 and 21.3 vs 20.2 mm2 for reader 2, respectively, P > .60 for both), or in second-order bile duct visualization score (2.34 vs 2.36 for reader 1 and 2.58 vs 2.50 for reader 2, respectively; P > .5 for both). Conclusion: The results suggest that premedication with intravenous morphine prior to CT cholangiography in potential liver donors does not increase bile duct caliber or improve biliary visualization.

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