CSF α-MSH in dementia of the Alzheimer type

I. Rainero, C. May, Jeffrey Kaye, R. P. Friedland, S. I. Rapoport

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We measured CSF a-melanocyte stimulating hormone-like immunoreactivity (a-MSH-LI) in 35 patients with dementia of the Alzheimer type (DAT) and in 27 healthy control subjects. Mean a-MSH-LI concentration was significantly decreased in DAT patients as compared with age-matched controls. However, when the DAT patients were analyzed according to age at onset of dementia or presence of extrapyramidal signs, α-MSH-LI concentrations remained significantly lower than in controls only in DAT patients with late onset of dementia (>65 years of age). No correlation was found between a-MSH levels and degree of mental impairment. A significant negative correlation was found between CSF concentrations of a-MSH and homovanillic acid in the group of all DAT patients (p <0.001). These results suggest that hypothalamic neurons which produce pro-opiornelanocortin -related peptides may be involved in Alzheimer’s disease.

Original languageEnglish (US)
Pages (from-to)1281-1284
Number of pages4
JournalNeurology
Volume38
Issue number8
StatePublished - 1988
Externally publishedYes

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Melanocyte-Stimulating Hormones
Alzheimer Disease
Dementia
Homovanillic Acid
Age of Onset
Alzheimer
Healthy Volunteers
Neurons
Peptides

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Rainero, I., May, C., Kaye, J., Friedland, R. P., & Rapoport, S. I. (1988). CSF α-MSH in dementia of the Alzheimer type. Neurology, 38(8), 1281-1284.

CSF α-MSH in dementia of the Alzheimer type. / Rainero, I.; May, C.; Kaye, Jeffrey; Friedland, R. P.; Rapoport, S. I.

In: Neurology, Vol. 38, No. 8, 1988, p. 1281-1284.

Research output: Contribution to journalArticle

Rainero, I, May, C, Kaye, J, Friedland, RP & Rapoport, SI 1988, 'CSF α-MSH in dementia of the Alzheimer type', Neurology, vol. 38, no. 8, pp. 1281-1284.
Rainero I, May C, Kaye J, Friedland RP, Rapoport SI. CSF α-MSH in dementia of the Alzheimer type. Neurology. 1988;38(8):1281-1284.
Rainero, I. ; May, C. ; Kaye, Jeffrey ; Friedland, R. P. ; Rapoport, S. I. / CSF α-MSH in dementia of the Alzheimer type. In: Neurology. 1988 ; Vol. 38, No. 8. pp. 1281-1284.
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