Cryptococcus neoformans: Virulence and host defences

J. R. Perfect, B. Wong, Y. C. Chang, K. J. Kwon-Chung, P. R. Williamson

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Cryptococcus neoformans represents a model organism for the study of virulence and the host response. In this discussion, there is a focus on the genetic, molecular, and biochemical aspects of C. neoformans as it interacts with the host. Investigations into direct and indirect virulence phenotypes are now possible. The molecular aspects of two major virulence factors, capsule and melanin, are characterized. Yeast polyol metabolism through mannitol is examined as a potential biochemical pathway for virulence. The concept of C. neoformans differentially expressed genes within the host or in response to certain environmental cues can be used indirectly to identify potential virulence genes. However, despite significant progress in molecular pathogenesis with C. neoformans, the future of research in this area will require a certain critical mass of investigators to help share in the developmental costs which continue to occur.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalMedical Mycology, Supplement
Volume36
Issue number1
StatePublished - Dec 1 1998

Keywords

  • Cryptococcus neoformans
  • Molecular biology
  • Virulence

ASJC Scopus subject areas

  • Microbiology
  • Immunology

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    Perfect, J. R., Wong, B., Chang, Y. C., Kwon-Chung, K. J., & Williamson, P. R. (1998). Cryptococcus neoformans: Virulence and host defences. Medical Mycology, Supplement, 36(1), 79-86.