Cryptococcus neoformans

Virulence and host defences

J. R. Perfect, Brian Wong, Y. C. Chang, K. J. Kwon-Chung, P. R. Williamson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cryptococcus neoformans represents a model organism for the study of virulence and the host response. In this discussion, there is a focus on the genetic, molecular, and biochemical aspects of C. neoformans as it interacts with the host. Investigations into direct and indirect virulence phenotypes are now possible. The molecular aspects of two major virulence factors, capsule and melanin, are characterized. Yeast polyol metabolism through mannitol is examined as a potential biochemical pathway for virulence. The concept of C. neoformans differentially expressed genes within the host or in response to certain environmental cues can be used indirectly to identify potential virulence genes. However, despite significant progress in molecular pathogenesis with C. neoformans, the future of research in this area will require a certain critical mass of investigators to help share in the developmental costs which continue to occur.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalJournal of Medical and Veterinary Mycology
Volume3
StatePublished - 1998
Externally publishedYes

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Cryptococcus neoformans
Virulence
Molecular Biology
Melanins
Mannitol
Virulence Factors
Genes
Capsules
Cues
Yeasts
Research Personnel
Phenotype
Costs and Cost Analysis
Research

Keywords

  • Cryptococcus neoformans
  • Molecular biology
  • Virulence

ASJC Scopus subject areas

  • Microbiology

Cite this

Perfect, J. R., Wong, B., Chang, Y. C., Kwon-Chung, K. J., & Williamson, P. R. (1998). Cryptococcus neoformans: Virulence and host defences. Journal of Medical and Veterinary Mycology, 3, 79-86.

Cryptococcus neoformans : Virulence and host defences. / Perfect, J. R.; Wong, Brian; Chang, Y. C.; Kwon-Chung, K. J.; Williamson, P. R.

In: Journal of Medical and Veterinary Mycology, Vol. 3, 1998, p. 79-86.

Research output: Contribution to journalArticle

Perfect, JR, Wong, B, Chang, YC, Kwon-Chung, KJ & Williamson, PR 1998, 'Cryptococcus neoformans: Virulence and host defences', Journal of Medical and Veterinary Mycology, vol. 3, pp. 79-86.
Perfect JR, Wong B, Chang YC, Kwon-Chung KJ, Williamson PR. Cryptococcus neoformans: Virulence and host defences. Journal of Medical and Veterinary Mycology. 1998;3:79-86.
Perfect, J. R. ; Wong, Brian ; Chang, Y. C. ; Kwon-Chung, K. J. ; Williamson, P. R. / Cryptococcus neoformans : Virulence and host defences. In: Journal of Medical and Veterinary Mycology. 1998 ; Vol. 3. pp. 79-86.
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