Crucial roles of histone-modifying enzymes in mediating neural cell-type specification

Seunghee Lee; Soo Kyung Lee

doi:10.1016/j.conb.2010.01.003

Crucial roles of histone-modifying enzymes in mediating neural cell-type specification

Seunghee Lee, Soo Kyung Lee

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

The development of the central nervous system (CNS) is governed by networks of extrinsic and intrinsic molecular programs that together orchestrate precise gene regulation. For the past few years, significant progress has been made in the characterization of histone-modifying enzymes and the roles they play in transcriptional control by affecting chromatin structure. Importantly, recent studies have revealed dynamic changes in histone modifications over the course of neural cell-fate specification. Further understanding of physiological functions of histone-modifying enzymes and their molecular mechanisms of action in CNS development will provide crucial insights into the process of generating neural cell types with tremendous diversity. Here we discuss the recent advancement in understanding the roles of enzymes involved in histone acetylation and methylation during neural cell-type specification.

Original language	English (US)
Pages (from-to)	29-36
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.conb.2010.01.003
State	Published - Feb 2010
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2010.01.003

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title = "Crucial roles of histone-modifying enzymes in mediating neural cell-type specification",

abstract = "The development of the central nervous system (CNS) is governed by networks of extrinsic and intrinsic molecular programs that together orchestrate precise gene regulation. For the past few years, significant progress has been made in the characterization of histone-modifying enzymes and the roles they play in transcriptional control by affecting chromatin structure. Importantly, recent studies have revealed dynamic changes in histone modifications over the course of neural cell-fate specification. Further understanding of physiological functions of histone-modifying enzymes and their molecular mechanisms of action in CNS development will provide crucial insights into the process of generating neural cell types with tremendous diversity. Here we discuss the recent advancement in understanding the roles of enzymes involved in histone acetylation and methylation during neural cell-type specification.",

author = "Seunghee Lee and Lee, {Soo Kyung}",

note = "Funding Information: We apologize to all the researchers whose important contributions could not be acknowledged because of space constraints. We thank Joanna Asprer and Jae W. Lee for stimulating discussions and comments on this manuscript. This work was supported by NIH/NINDS (R01 NS054941), PEW Scholars Program, and March of Dimes Foundation. ",

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AB - The development of the central nervous system (CNS) is governed by networks of extrinsic and intrinsic molecular programs that together orchestrate precise gene regulation. For the past few years, significant progress has been made in the characterization of histone-modifying enzymes and the roles they play in transcriptional control by affecting chromatin structure. Importantly, recent studies have revealed dynamic changes in histone modifications over the course of neural cell-fate specification. Further understanding of physiological functions of histone-modifying enzymes and their molecular mechanisms of action in CNS development will provide crucial insights into the process of generating neural cell types with tremendous diversity. Here we discuss the recent advancement in understanding the roles of enzymes involved in histone acetylation and methylation during neural cell-type specification.

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Crucial roles of histone-modifying enzymes in mediating neural cell-type specification

Abstract

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