Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

Nirmal K. Banda, Jacques Bernier, David K. Kurahara, Roland Kurrle, Nancy Haigwood, Rafik P. Sekaly, Terri Helman Finkel

Research output: Contribution to journalArticle

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Abstract

During human immunodeficiency virus (HIV) infection there is a profound and selective decrease in the CD4+ population of T lymphocytes. The mechanism of this depletion is not understood, as only a small fraction of all CD4+ cells appear to be productively infected with HIV-1 in seropositive individuals. In the present study, crosslinking of bound gp120 on human CD4+ T cells followed by signaling through the T cell receptor for antigen was found to result in activation-dependent cell death by a form of cell suicide termed apoptosis, or programmed cell death. The data indicate that even picomolar concentrations of gp120 prime T cells for activation-induced cell death, suggesting a mechanism for CD4+ T cell depletion in acquired immune deficiency syndrome (AIDS), particularly in the face of concurrent infection and antigenic challenge with other organisms. These results also provide an explanation for the enhancement of infection by certain antibodies against HIV, and for the paradox that HIV appears to cause AIDS after the onset of antiviral immunity.

Original languageEnglish (US)
Pages (from-to)1099-1106
Number of pages8
JournalJournal of Experimental Medicine
Volume176
Issue number4
StatePublished - Oct 1 1992
Externally publishedYes

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HIV
Apoptosis
T-Lymphocytes
Cell Death
Acquired Immunodeficiency Syndrome
Virus Diseases
T-Cell Antigen Receptor
Infection
Suicide
Antiviral Agents
HIV-1
Immunity
Antibodies
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Banda, N. K., Bernier, J., Kurahara, D. K., Kurrle, R., Haigwood, N., Sekaly, R. P., & Finkel, T. H. (1992). Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. Journal of Experimental Medicine, 176(4), 1099-1106.

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. / Banda, Nirmal K.; Bernier, Jacques; Kurahara, David K.; Kurrle, Roland; Haigwood, Nancy; Sekaly, Rafik P.; Finkel, Terri Helman.

In: Journal of Experimental Medicine, Vol. 176, No. 4, 01.10.1992, p. 1099-1106.

Research output: Contribution to journalArticle

Banda, NK, Bernier, J, Kurahara, DK, Kurrle, R, Haigwood, N, Sekaly, RP & Finkel, TH 1992, 'Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis', Journal of Experimental Medicine, vol. 176, no. 4, pp. 1099-1106.
Banda, Nirmal K. ; Bernier, Jacques ; Kurahara, David K. ; Kurrle, Roland ; Haigwood, Nancy ; Sekaly, Rafik P. ; Finkel, Terri Helman. / Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. In: Journal of Experimental Medicine. 1992 ; Vol. 176, No. 4. pp. 1099-1106.
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