Cross-talk between reproduction and energy homeostasis

Central impact of estrogens, leptin and kisspeptin signaling

Casey C. Nestor, Martin Kelly, Oline Ronnekleiv

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The central nervous system receives hormonal cues (e.g., estrogens and leptin, among others) that influence reproduction and energy homeostasis. 17β-estradiol (E2) is known to regulate gonadotropin-releasing hormone (GnRH) secretion via classical steroid signaling and rapid non-classical membrane-initiated signaling. Because GnRH neurons are void of leptin receptors, the actions of leptin on these neurons must be indirect. Although it is clear that the arcuate nucleus of the hypothalamus is the primary site of overlap between these two systems, it is still unclear which neural network(s) participate in the cross-talk of E2 and leptin, two hormones essential for reproductive function and metabolism. Herein we review the progress made in understanding the interactions between reproduction and energy homeostasis by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY). Although critical in mediating the actions of E2 and leptin, considerable work still remains to uncover how these neural networks interact in vivo.

Original languageEnglish (US)
Pages (from-to)109-128
Number of pages20
JournalHormone Molecular Biology and Clinical Investigation
Volume17
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Kisspeptins
Leptin
Reproduction
Estrogens
Homeostasis
Gonadotropin-Releasing Hormone
Neurons
Leptin Receptors
Pro-Opiomelanocortin
Arcuate Nucleus of Hypothalamus
Cues
Estradiol
Central Nervous System
Steroids
Hormones
Membranes

Keywords

  • 17β-estradiol
  • Kisspeptin
  • Leptin
  • Neuropeptide Y
  • Pro-opiomelanocortin

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

@article{15eb09a57029498b8e1c7a1b9d7cfcf0,
title = "Cross-talk between reproduction and energy homeostasis: Central impact of estrogens, leptin and kisspeptin signaling",
abstract = "The central nervous system receives hormonal cues (e.g., estrogens and leptin, among others) that influence reproduction and energy homeostasis. 17β-estradiol (E2) is known to regulate gonadotropin-releasing hormone (GnRH) secretion via classical steroid signaling and rapid non-classical membrane-initiated signaling. Because GnRH neurons are void of leptin receptors, the actions of leptin on these neurons must be indirect. Although it is clear that the arcuate nucleus of the hypothalamus is the primary site of overlap between these two systems, it is still unclear which neural network(s) participate in the cross-talk of E2 and leptin, two hormones essential for reproductive function and metabolism. Herein we review the progress made in understanding the interactions between reproduction and energy homeostasis by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY). Although critical in mediating the actions of E2 and leptin, considerable work still remains to uncover how these neural networks interact in vivo.",
keywords = "17β-estradiol, Kisspeptin, Leptin, Neuropeptide Y, Pro-opiomelanocortin",
author = "Nestor, {Casey C.} and Martin Kelly and Oline Ronnekleiv",
year = "2014",
doi = "10.1515/hmbci-2013-0050",
language = "English (US)",
volume = "17",
pages = "109--128",
journal = "Hormone Molecular Biology and Clinical Investigation",
issn = "1868-1883",
publisher = "Walter de Gruyter GmbH",
number = "3",

}

TY - JOUR

T1 - Cross-talk between reproduction and energy homeostasis

T2 - Central impact of estrogens, leptin and kisspeptin signaling

AU - Nestor, Casey C.

AU - Kelly, Martin

AU - Ronnekleiv, Oline

PY - 2014

Y1 - 2014

N2 - The central nervous system receives hormonal cues (e.g., estrogens and leptin, among others) that influence reproduction and energy homeostasis. 17β-estradiol (E2) is known to regulate gonadotropin-releasing hormone (GnRH) secretion via classical steroid signaling and rapid non-classical membrane-initiated signaling. Because GnRH neurons are void of leptin receptors, the actions of leptin on these neurons must be indirect. Although it is clear that the arcuate nucleus of the hypothalamus is the primary site of overlap between these two systems, it is still unclear which neural network(s) participate in the cross-talk of E2 and leptin, two hormones essential for reproductive function and metabolism. Herein we review the progress made in understanding the interactions between reproduction and energy homeostasis by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY). Although critical in mediating the actions of E2 and leptin, considerable work still remains to uncover how these neural networks interact in vivo.

AB - The central nervous system receives hormonal cues (e.g., estrogens and leptin, among others) that influence reproduction and energy homeostasis. 17β-estradiol (E2) is known to regulate gonadotropin-releasing hormone (GnRH) secretion via classical steroid signaling and rapid non-classical membrane-initiated signaling. Because GnRH neurons are void of leptin receptors, the actions of leptin on these neurons must be indirect. Although it is clear that the arcuate nucleus of the hypothalamus is the primary site of overlap between these two systems, it is still unclear which neural network(s) participate in the cross-talk of E2 and leptin, two hormones essential for reproductive function and metabolism. Herein we review the progress made in understanding the interactions between reproduction and energy homeostasis by focusing on the advances made to understand the cellular signaling of E2 and leptin on three neural networks: kisspeptin, pro-opiomelanocortin (POMC) and neuropeptide Y (NPY). Although critical in mediating the actions of E2 and leptin, considerable work still remains to uncover how these neural networks interact in vivo.

KW - 17β-estradiol

KW - Kisspeptin

KW - Leptin

KW - Neuropeptide Y

KW - Pro-opiomelanocortin

UR - http://www.scopus.com/inward/record.url?scp=84926610080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926610080&partnerID=8YFLogxK

U2 - 10.1515/hmbci-2013-0050

DO - 10.1515/hmbci-2013-0050

M3 - Article

VL - 17

SP - 109

EP - 128

JO - Hormone Molecular Biology and Clinical Investigation

JF - Hormone Molecular Biology and Clinical Investigation

SN - 1868-1883

IS - 3

ER -