Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol

    Research output: Chapter in Book/Report/Conference proceedingChapter

    3 Citations (Scopus)

    Abstract

    The progress on understanding the pharmacological basis of ethanol’s discriminative stimulus effects has been substantial, but appears to have plateaued in the past decade. Further, the cross-species translational efforts are clear in laboratory animals, but have been minimal in human subject studies. Research findings clearly demonstrate that ethanol produces a compound stimulus with primary activity through GABA and glutamate receptor systems, particularly ionotropic receptors, with additional contribution from serotonergic mechanisms. Further progress should capitalize on chemogenetic and optogenetic techniques in laboratory animals to identify the neural circuitry involved in mediating the discriminative stimulus effects of ethanol. These infrahuman studies can be guided by in vivo imaging of human brain circuitry mediating ethanol’s subjective effects. Ultimately, identifying receptors systems, as well as where they are located within brain circuitry, will transform the use of drug discrimination procedures to help identify possible treatment or prevention strategies for alcohol use disorder.

    Original languageEnglish (US)
    Title of host publicationCurrent Topics in Behavioral Neurosciences
    PublisherSpringer Verlag
    Pages95-111
    Number of pages17
    DOIs
    StatePublished - Jan 1 2018

    Publication series

    NameCurrent Topics in Behavioral Neurosciences
    Volume39
    ISSN (Print)1866-3370
    ISSN (Electronic)1866-3389

    Fingerprint

    Ethanol
    Laboratory Animals
    Optogenetics
    GABA Receptors
    Glutamate Receptors
    Neuroimaging
    Alcohols
    Pharmacology
    Brain
    Research
    Pharmaceutical Preparations

    Keywords

    • Alcohol
    • Drug discrimination
    • Ethanol
    • Interspecies
    • Translational

    ASJC Scopus subject areas

    • Behavioral Neuroscience

    Cite this

    Allen, D. C., Ford, M., & Grant, K. K. (2018). Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. In Current Topics in Behavioral Neurosciences (pp. 95-111). (Current Topics in Behavioral Neurosciences; Vol. 39). Springer Verlag. https://doi.org/10.1007/7854_2017_2

    Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. / Allen, Daicia C.; Ford, Matthew; Grant, Kathleen (Kathy).

    Current Topics in Behavioral Neurosciences. Springer Verlag, 2018. p. 95-111 (Current Topics in Behavioral Neurosciences; Vol. 39).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Allen, DC, Ford, M & Grant, KK 2018, Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. in Current Topics in Behavioral Neurosciences. Current Topics in Behavioral Neurosciences, vol. 39, Springer Verlag, pp. 95-111. https://doi.org/10.1007/7854_2017_2
    Allen DC, Ford M, Grant KK. Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. In Current Topics in Behavioral Neurosciences. Springer Verlag. 2018. p. 95-111. (Current Topics in Behavioral Neurosciences). https://doi.org/10.1007/7854_2017_2
    Allen, Daicia C. ; Ford, Matthew ; Grant, Kathleen (Kathy). / Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol. Current Topics in Behavioral Neurosciences. Springer Verlag, 2018. pp. 95-111 (Current Topics in Behavioral Neurosciences).
    @inbook{56b193e730fd4b01ab8ca62b10a95c8e,
    title = "Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol",
    abstract = "The progress on understanding the pharmacological basis of ethanol’s discriminative stimulus effects has been substantial, but appears to have plateaued in the past decade. Further, the cross-species translational efforts are clear in laboratory animals, but have been minimal in human subject studies. Research findings clearly demonstrate that ethanol produces a compound stimulus with primary activity through GABA and glutamate receptor systems, particularly ionotropic receptors, with additional contribution from serotonergic mechanisms. Further progress should capitalize on chemogenetic and optogenetic techniques in laboratory animals to identify the neural circuitry involved in mediating the discriminative stimulus effects of ethanol. These infrahuman studies can be guided by in vivo imaging of human brain circuitry mediating ethanol’s subjective effects. Ultimately, identifying receptors systems, as well as where they are located within brain circuitry, will transform the use of drug discrimination procedures to help identify possible treatment or prevention strategies for alcohol use disorder.",
    keywords = "Alcohol, Drug discrimination, Ethanol, Interspecies, Translational",
    author = "Allen, {Daicia C.} and Matthew Ford and Grant, {Kathleen (Kathy)}",
    year = "2018",
    month = "1",
    day = "1",
    doi = "10.1007/7854_2017_2",
    language = "English (US)",
    series = "Current Topics in Behavioral Neurosciences",
    publisher = "Springer Verlag",
    pages = "95--111",
    booktitle = "Current Topics in Behavioral Neurosciences",
    address = "Germany",

    }

    TY - CHAP

    T1 - Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol

    AU - Allen, Daicia C.

    AU - Ford, Matthew

    AU - Grant, Kathleen (Kathy)

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - The progress on understanding the pharmacological basis of ethanol’s discriminative stimulus effects has been substantial, but appears to have plateaued in the past decade. Further, the cross-species translational efforts are clear in laboratory animals, but have been minimal in human subject studies. Research findings clearly demonstrate that ethanol produces a compound stimulus with primary activity through GABA and glutamate receptor systems, particularly ionotropic receptors, with additional contribution from serotonergic mechanisms. Further progress should capitalize on chemogenetic and optogenetic techniques in laboratory animals to identify the neural circuitry involved in mediating the discriminative stimulus effects of ethanol. These infrahuman studies can be guided by in vivo imaging of human brain circuitry mediating ethanol’s subjective effects. Ultimately, identifying receptors systems, as well as where they are located within brain circuitry, will transform the use of drug discrimination procedures to help identify possible treatment or prevention strategies for alcohol use disorder.

    AB - The progress on understanding the pharmacological basis of ethanol’s discriminative stimulus effects has been substantial, but appears to have plateaued in the past decade. Further, the cross-species translational efforts are clear in laboratory animals, but have been minimal in human subject studies. Research findings clearly demonstrate that ethanol produces a compound stimulus with primary activity through GABA and glutamate receptor systems, particularly ionotropic receptors, with additional contribution from serotonergic mechanisms. Further progress should capitalize on chemogenetic and optogenetic techniques in laboratory animals to identify the neural circuitry involved in mediating the discriminative stimulus effects of ethanol. These infrahuman studies can be guided by in vivo imaging of human brain circuitry mediating ethanol’s subjective effects. Ultimately, identifying receptors systems, as well as where they are located within brain circuitry, will transform the use of drug discrimination procedures to help identify possible treatment or prevention strategies for alcohol use disorder.

    KW - Alcohol

    KW - Drug discrimination

    KW - Ethanol

    KW - Interspecies

    KW - Translational

    UR - http://www.scopus.com/inward/record.url?scp=85052876530&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85052876530&partnerID=8YFLogxK

    U2 - 10.1007/7854_2017_2

    DO - 10.1007/7854_2017_2

    M3 - Chapter

    C2 - 28341943

    AN - SCOPUS:85052876530

    T3 - Current Topics in Behavioral Neurosciences

    SP - 95

    EP - 111

    BT - Current Topics in Behavioral Neurosciences

    PB - Springer Verlag

    ER -