Cross-species molecular dissection across alcohol behavioral domains

Sean P. Farris, Brien P. Riley, Robert W. Williams, Megan K. Mulligan, Michael F. Miles, Marcelo F. Lopez, Robert Hitzemann, Ovidiu Iancu, Alexander Colville, Nicole A.R. Walter, Priscila Darakjian, Denesa L. Oberbeck, James B. Daunais, Christina Zheng, Robert Searles, Shannon McWeeney, Kathleen (Kathy) Grant, R. Dayne Mayfield

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

This review summarizes the proceedings of a symposium presented at the “Alcoholism and Stress: A Framework for Future Treatment Strategies” conference held in Volterra, Italy on May 9–12, 2017. Psychiatric diseases, including alcohol-use disorders (AUDs), are influenced through complex interactions of genes, neurobiological pathways, and environmental influences. A better understanding of the common neurobiological mechanisms underlying an AUD necessitates an integrative approach, involving a systematic assessment of diverse species and phenotype measures. As part of the World Congress on Stress and Alcoholism, this symposium provided a detailed account of current strategies to identify mechanisms underlying the development and progression of AUDs. Dr. Sean Farris discussed the integration and organization of transcriptome and postmortem human brain data to identify brain regional- and cell type-specific differences related to excessive alcohol consumption that are conserved across species. Dr. Brien Riley presented the results of a genome-wide association study of DSM-IV alcohol dependence; although replication of genetic associations with alcohol phenotypes in humans remains challenging, model organism studies show that COL6A3, KLF12, and RYR3 affect behavioral responses to ethanol, and provide substantial evidence for their role in human alcohol-related traits. Dr. Rob Williams expanded upon the systematic characterization of extensive genetic-genomic resources for quantifying and clarifying phenotypes across species that are relevant to precision medicine in human disease. The symposium concluded with Dr. Robert Hitzemann's description of transcriptome studies in a mouse model selectively bred for high alcohol (“binge-like”) consumption and a non-human primate model of long-term alcohol consumption. Together, the different components of this session provided an overview of systems-based approaches that are pioneering the experimental prioritization and validation of novel genes and gene networks linked with a range of behavioral phenotypes associated with stress and AUDs.

Original languageEnglish (US)
Pages (from-to)19-31
Number of pages13
JournalAlcohol
Volume72
DOIs
StatePublished - Nov 1 2018

Fingerprint

Dissection
alcohol
Alcohols
Alcoholism
Phenotype
Genes
Transcriptome
Alcohol Drinking
alcohol consumption
alcoholism
brain
Precision Medicine
Disease
Brain
Gene Regulatory Networks
Genome-Wide Association Study
Diagnostic and Statistical Manual of Mental Disorders
Primates
Italy
Psychiatry

Keywords

  • Alcohol-use disorder
  • Co-expression networks
  • Genome-wide association study
  • Recombinant inbred mice
  • RNA-Seq
  • Species conservation
  • Systems biology
  • Transcriptome

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Cite this

Farris, S. P., Riley, B. P., Williams, R. W., Mulligan, M. K., Miles, M. F., Lopez, M. F., ... Mayfield, R. D. (2018). Cross-species molecular dissection across alcohol behavioral domains. Alcohol, 72, 19-31. https://doi.org/10.1016/j.alcohol.2017.11.036

Cross-species molecular dissection across alcohol behavioral domains. / Farris, Sean P.; Riley, Brien P.; Williams, Robert W.; Mulligan, Megan K.; Miles, Michael F.; Lopez, Marcelo F.; Hitzemann, Robert; Iancu, Ovidiu; Colville, Alexander; Walter, Nicole A.R.; Darakjian, Priscila; Oberbeck, Denesa L.; Daunais, James B.; Zheng, Christina; Searles, Robert; McWeeney, Shannon; Grant, Kathleen (Kathy); Mayfield, R. Dayne.

In: Alcohol, Vol. 72, 01.11.2018, p. 19-31.

Research output: Contribution to journalReview article

Farris, SP, Riley, BP, Williams, RW, Mulligan, MK, Miles, MF, Lopez, MF, Hitzemann, R, Iancu, O, Colville, A, Walter, NAR, Darakjian, P, Oberbeck, DL, Daunais, JB, Zheng, C, Searles, R, McWeeney, S, Grant, KK & Mayfield, RD 2018, 'Cross-species molecular dissection across alcohol behavioral domains', Alcohol, vol. 72, pp. 19-31. https://doi.org/10.1016/j.alcohol.2017.11.036
Farris SP, Riley BP, Williams RW, Mulligan MK, Miles MF, Lopez MF et al. Cross-species molecular dissection across alcohol behavioral domains. Alcohol. 2018 Nov 1;72:19-31. https://doi.org/10.1016/j.alcohol.2017.11.036
Farris, Sean P. ; Riley, Brien P. ; Williams, Robert W. ; Mulligan, Megan K. ; Miles, Michael F. ; Lopez, Marcelo F. ; Hitzemann, Robert ; Iancu, Ovidiu ; Colville, Alexander ; Walter, Nicole A.R. ; Darakjian, Priscila ; Oberbeck, Denesa L. ; Daunais, James B. ; Zheng, Christina ; Searles, Robert ; McWeeney, Shannon ; Grant, Kathleen (Kathy) ; Mayfield, R. Dayne. / Cross-species molecular dissection across alcohol behavioral domains. In: Alcohol. 2018 ; Vol. 72. pp. 19-31.
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