Cross-sectional and longitudinal assessment of retinal sensitivity in patients with childhood-onset stargardt disease

Preena Tanna, Michalis Georgiou, Jonathan Aboshiha, Rupert W. Strauss, Neruban Kumaran, Angelos Kalitzeos, Richard Weleber, Michel Michaelides

Research output: Contribution to journalArticle

Abstract

Purpose: We assess cross-sectional and longitudinal microperimetry and full-field static perimetry-derived retinal sensitivity with conventional and volumetric indices of retinal function in childhood-onset Stargardt disease (STGD1). Methods: Subjects with molecularly confirmed childhood-onset STGD1 underwent full-field static perimetry and/or microperimetry using custom designed grids. Mean sensitivity (MS) and total volume (VTOT) were computed for each microperimetry test. MS, VTOT, and central field volume (V30) were computed for each full-field static perimetry test. Subjects under 18 years old at baseline were classified as children and subjects 18 years or older as adults. Results: A total of 43 children (mean age at baseline, 13.0 years; range, 8–17) and 13 adults (mean age at baseline, 23.1 years; range, 18–32) were included in the analysis. For full-field static perimetry and microperimetry for both subgroups, intraclass correlation coefficient results for MS and volumetric indices were good to excellent, indicating strong test–retest reliability. Interocular symmetry in terms of baseline measurements and the annual rate of progression was observed. A greater rate of progression was observed in childhood. Conclusions: To our knowledge, this is the first prospective study of retinal sensitivity in a large cohort of molecularly confirmed subjects with childhood-onset STGD1 demonstrating that children with STGD1 can reliably undertake detailed functional testing. Moreover, using custom designed grids and subsequent topographic analysis, volumetric indices of retinal function provide a reliable measure of retinal sensitivity. Translational Relevance: This study highlights the use of microperimetry and full-field static perimetry, as well as volumetric indices of retinal function, in monitoring disease progression.

Original languageEnglish (US)
Article number10
JournalTranslational Vision Science and Technology
Volume7
Issue number6
DOIs
StatePublished - Nov 1 2018

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Visual Field Tests
Volumetric analysis
Monitoring
Testing
Disease Progression
Stargardt disease 1
Prospective Studies

Keywords

  • ABCA4
  • Clinical trials
  • Endpoints
  • Perimetry
  • Retina
  • Retinal sensitivity
  • Stargardt disease
  • STGD1
  • Visual field

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

Cite this

Cross-sectional and longitudinal assessment of retinal sensitivity in patients with childhood-onset stargardt disease. / Tanna, Preena; Georgiou, Michalis; Aboshiha, Jonathan; Strauss, Rupert W.; Kumaran, Neruban; Kalitzeos, Angelos; Weleber, Richard; Michaelides, Michel.

In: Translational Vision Science and Technology, Vol. 7, No. 6, 10, 01.11.2018.

Research output: Contribution to journalArticle

Tanna, Preena ; Georgiou, Michalis ; Aboshiha, Jonathan ; Strauss, Rupert W. ; Kumaran, Neruban ; Kalitzeos, Angelos ; Weleber, Richard ; Michaelides, Michel. / Cross-sectional and longitudinal assessment of retinal sensitivity in patients with childhood-onset stargardt disease. In: Translational Vision Science and Technology. 2018 ; Vol. 7, No. 6.
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abstract = "Purpose: We assess cross-sectional and longitudinal microperimetry and full-field static perimetry-derived retinal sensitivity with conventional and volumetric indices of retinal function in childhood-onset Stargardt disease (STGD1). Methods: Subjects with molecularly confirmed childhood-onset STGD1 underwent full-field static perimetry and/or microperimetry using custom designed grids. Mean sensitivity (MS) and total volume (VTOT) were computed for each microperimetry test. MS, VTOT, and central field volume (V30) were computed for each full-field static perimetry test. Subjects under 18 years old at baseline were classified as children and subjects 18 years or older as adults. Results: A total of 43 children (mean age at baseline, 13.0 years; range, 8–17) and 13 adults (mean age at baseline, 23.1 years; range, 18–32) were included in the analysis. For full-field static perimetry and microperimetry for both subgroups, intraclass correlation coefficient results for MS and volumetric indices were good to excellent, indicating strong test–retest reliability. Interocular symmetry in terms of baseline measurements and the annual rate of progression was observed. A greater rate of progression was observed in childhood. Conclusions: To our knowledge, this is the first prospective study of retinal sensitivity in a large cohort of molecularly confirmed subjects with childhood-onset STGD1 demonstrating that children with STGD1 can reliably undertake detailed functional testing. Moreover, using custom designed grids and subsequent topographic analysis, volumetric indices of retinal function provide a reliable measure of retinal sensitivity. Translational Relevance: This study highlights the use of microperimetry and full-field static perimetry, as well as volumetric indices of retinal function, in monitoring disease progression.",
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